Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/241513
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
DC FieldValueLanguage
dc.contributor.authorHerrera, Antonio-
dc.contributor.authorMenendez, Anghara-
dc.contributor.authorTorroba, Blanca-
dc.contributor.authorOchoa, Andrea-
dc.contributor.authorPons, Sebastián-
dc.date.accessioned2021-05-24T17:20:05Z-
dc.date.available2021-05-24T17:20:05Z-
dc.date.issued2021-06-07-
dc.identifier.citationJournal of Cell Biology 220(6): e202007055 (2021)-
dc.identifier.issn0021-9525-
dc.identifier.urihttp://hdl.handle.net/10261/241513-
dc.description.abstractThe neural tube forms when neural stem cells arrange into a pseudostratified, single-cell–layered epithelium, with a marked apico-basal polarity, and in which adherens junctions (AJs) concentrate in the subapical domain. We previously reported that sustained β-catenin expression promotes the formation of enlarged apical complexes (ACs), enhancing apico-basal polarity, although the mechanism through which this occurs remained unclear. Here, we show that β-catenin interacts with phosphorylated pro-N-cadherin early in its transit through the Golgi apparatus, promoting propeptide excision and the final maturation of N-cadherin. We describe a new β-catenin–dependent interaction of N-cadherin with Drebrin-like (Dbnl), an actin-binding protein that is involved in anterograde Golgi trafficking of proteins. Notably, Dbnl knockdown led to pro-N-cadherin accumulation and limited AJ formation. In brief, we demonstrate that Dbnl and β-catenin assist in the maturation of pro-N-cadherin, which is critical for AJ formation and for the recruitment AC components like aPKC and, consequently, for the maintenance of apico-basal polarity.-
dc.description.sponsorshipMinisterio de Economía y Competitividad (BFU2014-53633-P)-
dc.languageeng-
dc.publisherRockefeller University Press-
dc.relationMINECO/ICTI2013-2016/BFU2014-53633-P-
dc.relation.isversionofPublisher's version-
dc.rightsclosedAccess-
dc.subjectAdhesion-
dc.subjectDevelopment-
dc.subjectPolarity-
dc.titleDbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity-
dc.typeartículo-
dc.identifier.doi10.1083/jcb.202007055-
dc.relation.publisherversionhttp://dx.doi.org/10.1083/jcb.202007055-
dc.identifier.e-issn1540-8140-
dc.date.updated2021-05-24T17:20:06Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-sa/4.0/-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
item.fulltextNo Fulltext-
item.openairetypeartículo-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.