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Title

Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity

AuthorsHerrera, Antonio CSIC ORCID ; Menendez, Anghara CSIC ; Torroba, Blanca; Ochoa, Andrea; Pons, Sebastián CSIC ORCID
KeywordsAdhesion
Development
Polarity
Issue Date7-Jun-2021
PublisherRockefeller University Press
CitationJournal of Cell Biology 220(6): e202007055 (2021)
AbstractThe neural tube forms when neural stem cells arrange into a pseudostratified, single-cell–layered epithelium, with a marked apico-basal polarity, and in which adherens junctions (AJs) concentrate in the subapical domain. We previously reported that sustained β-catenin expression promotes the formation of enlarged apical complexes (ACs), enhancing apico-basal polarity, although the mechanism through which this occurs remained unclear. Here, we show that β-catenin interacts with phosphorylated pro-N-cadherin early in its transit through the Golgi apparatus, promoting propeptide excision and the final maturation of N-cadherin. We describe a new β-catenin–dependent interaction of N-cadherin with Drebrin-like (Dbnl), an actin-binding protein that is involved in anterograde Golgi trafficking of proteins. Notably, Dbnl knockdown led to pro-N-cadherin accumulation and limited AJ formation. In brief, we demonstrate that Dbnl and β-catenin assist in the maturation of pro-N-cadherin, which is critical for AJ formation and for the recruitment AC components like aPKC and, consequently, for the maintenance of apico-basal polarity.
Publisher version (URL)http://dx.doi.org/10.1083/jcb.202007055
URIhttp://hdl.handle.net/10261/241513
DOIhttp://dx.doi.org/10.1083/jcb.202007055
ISSN0021-9525
E-ISSN1540-8140
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