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Title

Antiviral properties of supercritical CO2 extracts from oregano and sage

AuthorsSantoyo, Susana CSIC ORCID ; Jaime, Laura CSIC ORCID ; García-Risco, Mónica R. CSIC ; Ruiz-Rodríguez, Alejandro CSIC ; Reglero, Guillermo CSIC ORCID
Issue Date2014
PublisherTaylor & Francis
CitationInternational Journal of Food Properties 17(5): 1150-1161 (2014)
AbstractThe antiviral properties of supercritical CO2 extracts obtained from oregano and sage were evaluated against the herpes simplex virus type 1 at different stages during virus infection. All of the extracts tested presented a moderate extracellular direct virucidal activity, although a pre-treatment of Vero cells, with 10 μg/mL of sage extracts before virus addition, inhibited 70% of the virus infection. Moreover, supercritical extracts of sage and oregano were able to significantly inhibit the in vitro virus replication, showing IC50 values of 1.88 and 5.33 μg/mL, respectively. Carvacrol and thymol could be pointed out as the compounds responsible for the antiviral activity found in oregano supercritical extracts; meanwhile, borneol, camphor, and 1,8-cineole could be proposed as antiviral compounds in supercritical sage extracts. Results demonstrated that supercritical extraction was an appropriate technique to obtain antiviral extracts from oregano and sage.
Publisher version (URL)https://doi.org/10.1080/10942912.2012.700539
URIhttp://hdl.handle.net/10261/241044
DOI10.1080/10942912.2012.700539
E-ISSN1532-2386
Appears in Collections:(CIAL) Artículos




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