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dc.contributor.authorBurbano, Hernán A.-
dc.contributor.authorHodges, Emily-
dc.contributor.authorGreen, Richard E.-
dc.contributor.authorBriggs, Adrian W.-
dc.contributor.authorKrause, Johannes-
dc.contributor.authorMeyer, Matthias-
dc.contributor.authorGood, Jeffrey M.-
dc.contributor.authorMaricic, Tomislav-
dc.contributor.authorJohnson, Philip L. F.-
dc.contributor.authorXuan, Zhenyu-
dc.contributor.authorRooks, Michelle-
dc.contributor.authorBhattacharjee, Arindam-
dc.contributor.authorBrizuela, Leonardo-
dc.contributor.authorAlbert, Frank W.-
dc.contributor.authorRasilla, Marco de la-
dc.contributor.authorFortea, Javier-
dc.contributor.authorRosas, Antonio-
dc.contributor.authorLachmann, Michael-
dc.contributor.authorHannon, Gregory J.-
dc.contributor.authorPääbo, Svante-
dc.identifier.citationSciencie 328(5979): 723-725 (2010)en_US
dc.description3 pages, 2 figures.en_US
dc.description.abstractIt is now possible to perform whole-genome shotgun sequencing as well as capture of specific genomic regions for extinct organisms. However, targeted resequencing of large parts of nuclear genomes has yet to be demonstrated for ancient DNA. Here we show that hybridization capture on microarrays can successfully recover more than a megabase of target regions from Neandertal DNA even in the presence of ~99.8% microbial DNA. Using this approach, we have sequenced ~14,000 protein-coding positions inferred to have changed on the human lineage since the last common ancestor shared with chimpanzees. By generating the sequence of one Neandertal and 50 present-day humans at these positions, we have identified 88 amino acid substitutions that have become fixed in humans since our divergence from the Neandertals.en_US
dc.description.sponsorshipThe government of the Principado de Asturias funded excavations at the Sidrón site. J.M.G. was supported by an NSF international postdoctoral fellowship (OISE-0754461) and E.H. by a postdoctoral training grant from the NIH and by a gift from the Stanley Foundation. G.J.H. is an investigator of the Howard Hughes Medical Institute, which together with the Presidential Innovation Fund of the Max Planck Society provided generous financial support.en_US
dc.format.extent142854 bytes-
dc.publisherAAS Division of Planetary Sciencesen_US
dc.titleTargeted Investigation of the Neandertal Genome by Array-Based Sequence Capture.en_US
dc.description.peerreviewedPeer revieweden_US
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