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Título: | Editorial: Neuronal Calcium Sensors in Health and Disease |
Autor: | Dell'Orco, Daniele; Koch, Karl-Wilhelm; Kreutz, Michael R.; Naranjo, José Ramón CSIC ORCID; Schwaller, Beat | Palabras clave: | Neuronal Ca2+ sensors Calcium signaling Molecular basis of disease Calcium binding proteins Neurological disorders |
Fecha de publicación: | 15-nov-2019 | Editor: | Frontiers Media | Citación: | Frontiers in Molecular Neuroscience 12: 278 (2019) | Resumen: | The precise detection and regulation of free intracellular Ca2+ is a prerequisite for keeping normal cell function. Several physiological processes such as fertilization, apoptosis, muscle contraction, neuronal activity, and sensory perception are based on the spatial and temporal variation in intracellular Ca2+ and rely on a class of proteins that specifically respond to these highly dynamic stimuli. Neuronal calcium sensor (NCS) proteins are exclusively expressed or enriched in neurons, and their structural and biochemical diversity reflects the multiplicity of their biological roles, which include control of gene transcription, neuronal growth and survival, channel and receptor regulation, neurotransmitter release, synaptic plasticity, and regulation of enzymatic activity. Neurological disorders and neurodegenerative diseases are increasingly associated with altered functions of specific NCS proteins. This Research Topic includes original articles and reviews that provide an interdisciplinary collection of up-to-date biochemical and biophysical research on NCS proteins and their established and novel biological roles in normal and altered (pathological) conditions. | Descripción: | © 2019 Dell'Orco, Koch, Kreutz, Naranjo and Schwaller. | Versión del editor: | http://dx.doi.org/10.3389/fnmol.2019.00278 | URI: | http://hdl.handle.net/10261/240238 | DOI: | 10.3389/fnmol.2019.00278 | Identificadores: | doi: 10.3389/fnmol.2019.00278 e-issn: 1662-5099 |
Aparece en las colecciones: | (CNB) Artículos |
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