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Título: | An equilibrium model for the Mg2+-linked self-assembly of FtsZ in the presence of GTP or a GTP analogue |
Autor: | Monterroso, Begoña CSIC ORCID ; Rivas, Germán CSIC ORCID CVN ; Minton, Allen P. | Palabras clave: | Nanofibers Monomers Cyclization Oligomers Scattering |
Fecha de publicación: | 18-jul-2012 | Editor: | American Chemical Society | Citación: | Biochemistry 51 (31) 6108-6113 (2012) | Resumen: | The concerted formation of a narrow distribution of oligomeric FtsZ species in the presence of GTP or a GTP analogue under close to physiological conditions (neutral pH and 0.5 M K+) has been characterized recently by various biophysical methods [Monterroso, B., et al. (2012) Biochemistry51, 4541–4550]. An equilibrium model may semiquantitatively account for the results of this study; in the model, FtsZ self-associates in a noncooperative fashion to form linear fibrils, that upon increasing to a certain size exhibit an increasing tendency to form closed cyclic fibrils, as previously suggested [González, J. M., et al. (2005) Proc. Natl. Acad. Sci. U.S.A.102, 1895–1900]. The closed cyclic fibrils are formed when the natural curvature and flexibility of a linear oligomer bring the ends of a linear fiber sufficiently close to overcome the entropic barrier to loop closure. The size distribution of cyclic oligomers is thus a reflection of the tendency toward curvature of linear fibrils of FtsZ under the conditions used in these experiments. | Descripción: | 6 p.-4 fig.-2 tab.-1 graph. abst. | Versión del editor: | https://doi.org/10.1021/bi300891q | URI: | http://hdl.handle.net/10261/240005 | DOI: | 10.1021/bi300891q | ISSN: | 0006-2960 | E-ISSN: | 1520-4995 |
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