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dc.contributor.authorGarcía-León, Martaes_ES
dc.contributor.authorCuyas, Lauraes_ES
dc.contributor.authorEl-Moneim, Diaa Abdes_ES
dc.contributor.authorRodriguez, Lesiaes_ES
dc.contributor.authorBelda-Palazón, Borjaes_ES
dc.contributor.authorSánchez-Quant, Evaes_ES
dc.contributor.authorFernández, Yolandaes_ES
dc.contributor.authorRoux, Bricees_ES
dc.contributor.authorZamarreño, Ángel M.es_ES
dc.contributor.authorGarcía-Mina, José Maríaes_ES
dc.contributor.authorNussaume, Laurentes_ES
dc.contributor.authorRodríguez, Pedro L.es_ES
dc.contributor.authorPaz-Ares, Javieres_ES
dc.contributor.authorLeonhardt, Nathaliees_ES
dc.contributor.authorRubio, Vicentees_ES
dc.date.accessioned2021-05-05T13:00:08Z-
dc.date.available2021-05-05T13:00:08Z-
dc.date.issued2019-10-
dc.identifierdoi: 10.1105/tpc.19.00399-
dc.identifierissn: 1040-4651-
dc.identifiere-issn: 1532-298X-
dc.identifier.citationPlant Cell 31(10): 2411-2429 (2019)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/239922-
dc.description.abstractThe plant endosomal trafficking pathway controls the abundance of membrane-associated soluble proteins, as shown for abscisic acid (ABA) receptors of the PYRABACTIN RESISTANCE1/PYR1-LIKE/REGULATORY COMPONENTS OF ABA RECEPTORS (PYR/PYL/RCAR) family. ABA receptor targeting for vacuolar degradation occurs through the late endosome route and depends on FYVE DOMAIN PROTEIN REQUIRED FOR ENDOSOMAL SORTING1 (FYVE1) and VACUOLAR PROTEIN SORTING23A (VPS23A), components of the ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT-I (ESCRT-I) complexes. FYVE1 and VPS23A interact with ALG-2 INTERACTING PROTEIN-X (ALIX), an ESCRT-III–associated protein, although the functional relevance of such interactions and their consequences in cargo sorting are unknown. In this study we show that Arabidopsis (Arabidopsis thaliana) ALIX directly binds to ABA receptors in late endosomes, promoting their degradation. Impaired ALIX function leads to altered endosomal localization and increased accumulation of ABA receptors. In line with this activity, partial loss-of-function alix-1 mutants display ABA hypersensitivity during growth and stomatal closure, unveiling a role for the ESCRT machinery in the control of water loss through stomata. ABA-hypersensitive responses are suppressed in alix-1 plants impaired in PYR/PYL/RCAR activity, in accordance with ALIX affecting ABA responses primarily by controlling ABA receptor stability. ALIX-1 mutant protein displays reduced interaction with VPS23A and ABA receptors, providing a molecular basis for ABA hypersensitivity in alix-1 mutants. Our findings unveil a negative feedback mechanism triggered by ABA that acts via ALIX to control the accumulation of specific PYR/PYL/RCAR receptors.-
dc.description.sponsorshipThis research was supported by the Ministerio de Economía y Competitividad (MINECO) and AEI/FEDER/EU (grants BIO2013-46539-R and BIO2016-80551-R to V.R., and BIO2017-82503-R to P.L.R.); by the Spanish Ministry of Education FPI “Severo Ochoa” fellowships (BES2015-071820 to M.G.-L.); by the European Molecular Biology Organization (EMBO) Short-Term programs (ASTF 7678-2016); by the Agence Nationale de Recherche REGLISSE project (ANR-13-ADAP-0008 to L.C.); by an Agencia Española de Cooperación Internacional (AECID) fellowship to D.A.E.-M.; by the Spanish Ministry of Education “Salvador de Madariaga” grant (PRX15/00493 to V.R.); and by Generalitat Valenciana “Programa VALi1d” (APOSTD/2017/039 to B.B.P.).-
dc.languageeng-
dc.publisherAmerican Society of Plant Biologistses_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2013-46539-R-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2016-80551-R-
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BIO2017-82503-R-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2013-0347-04-
dc.relationBIO2017-82503-R/AEI/10.13039/501100011033-
dc.rightsclosedAccess-
dc.titleArabidopsis ALIX Regulates Stomatal Aperture and Turnover of Abscisic Acid Receptorses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1105/tpc.19.00399-
dc.relation.publisherversionhttp://dx.doi.org/10.1105/tpc.19.00399-
dc.date.updated2021-05-05T13:00:08Z-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)-
dc.contributor.funderAgencia Estatal de Investigación (España)-
dc.contributor.funderAgence Nationale de la Recherche (France)-
dc.contributor.funderMinisterio de Educación (España)-
dc.contributor.funderGeneralitat Valenciana-
dc.contributor.funderEMBO-
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003043es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001665es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
dc.identifier.pmid31363038-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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