Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/239865
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A Neutrophil Timer Coordinates Immune Defense and Vascular Protection |
Autor: | Adrover, José M.; Fresno, Carlos del; Crainiciuc, Georgiana; Cuartero, María Isabel; Casanova-Acebes, María; Weiss, L.A.; Huerga Encabo, Héctor; Silvestre-Roig, C.; Rossaint, Jan; Cossío, Itziar; Lechuga-Vieco, Ana V.; García-Prieto, Jaime; Gómez-Parrizas, Mónica; Quintana, Juan A.; Ballesteros, Iván; Martin-Salamanca, Sandra; Aroca-Crevillen, Alejandra; Zhen Chong, Shu; Evrard, Maximilien; Balabanian, Karl; López, Jorge; Bidzhekov, Kiril; Bachelerie, Françoise; Abad-Santos, Francisco; Muñoz-Calleja, Cecilia; Zarbock, Alexander; Soehnlein, Oliver; Weber, C.; Guan Ng, Lai; López-Rodríguez, Cristina; Sancho, David; Moro, María A.; Ibáñez, Borja; Hidalgo, Andrés CSIC ORCID | Palabras clave: | Neutrophil Circadian clock Inflammation Infection Myocardial infarction Neutrophil aging Candida albicans Bmal 1CXCR2 CXCR4 |
Fecha de publicación: | 19-feb-2019 | Editor: | Elsevier | Citación: | Immunity 50(2): 390-402.e10 (2019) | Resumen: | Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they over-activate within blood vessels. It is unclear how immunity solves the dilemma of mounting an efficient anti-microbial defense while preserving vascular health. Here, we identify a neutrophil-intrinsic program that enabled both. The gene Bmal1 regulated expression of the chemokine CXCL2 to induce chemokine receptor CXCR2-dependent diurnal changes in the transcriptional and migratory properties of circulating neutrophils. These diurnal alterations, referred to as neutrophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer topology of neutrophils to favor homeostatic egress from blood vessels at night, resulting in boosted anti-microbial activity in tissues. Mice engineered for constitutive neutrophil aging became resistant to infection, but the persistence of intravascular aged neutrophils predisposed them to thrombo-inflammation and death. Thus, diurnal compartmentalization of neutrophils, driven by an internal timer, coordinates immune defense and vascular protection. Neutrophils display circadian oscillations in numbers and phenotype in the circulation. Adrover and colleagues now identify the molecular regulators of neutrophil aging and show that genetic disruption of this process has major consequences in immune cell trafficking, anti-microbial defense, and vascular health. | Versión del editor: | http://dx.doi.org/10.1016/j.immuni.2019.01.002 | URI: | http://hdl.handle.net/10261/239865 | DOI: | 10.1016/j.immuni.2019.01.002 | Identificadores: | doi: 10.1016/j.immuni.2019.01.002 issn: 1074-7613 e-issn: 1097-4180 |
Aparece en las colecciones: | (CNB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
224
checked on 09-abr-2024
WEB OF SCIENCETM
Citations
225
checked on 26-feb-2024
Page view(s)
85
checked on 18-abr-2024
Download(s)
22
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.