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Título: | Dense sampling of bird diversity increases power of comparative genomics |
Autor: | Feng, Shaohong; Stiller, Josefin; Deng, Yuan; Armstrong, Joel; Fang, Qi; Hart Reeve, Andrew; Milá, Borja CSIC ORCID | Fecha de publicación: | 12-nov-2020 | Editor: | Nature Publishing Group | Citación: | Nature 587: 252-257 (2020) | Resumen: | Whole-genome sequencing projects are increasingly populating the tree of life and characterizing biodiversity. Sparse taxon sampling has previously been proposed to confound phylogenetic inference, and captures only a fraction of the genomic diversity. Here we report a substantial step towards the dense representation of avian phylogenetic and molecular diversity, by analysing 363 genomes from 92.4% of bird families—including 267 newly sequenced genomes produced for phase II of the Bird 10,000 Genomes (B10K) Project. We use this comparative genome dataset in combination with a pipeline that leverages a reference-free whole-genome alignment to identify orthologous regions in greater numbers than has previously been possible and to recognize genomic novelties in particular bird lineages. The densely sampled alignment provides a single-base-pair map of selection, has more than doubled the fraction of bases that are confidently predicted to be under conservation and reveals extensive patterns of weak selection in predominantly non-coding DNA. Our results demonstrate that increasing the diversity of genomes used in comparative studies can reveal more shared and lineage-specific variation, and improve the investigation of genomic characteristics. We anticipate that this genomic resource will offer new perspectives on evolutionary processes in cross-species comparative analyses and assist in efforts to conserve species. | Versión del editor: | http://dx.doi.org/10.1038/s41586-020-2873-9 | URI: | http://hdl.handle.net/10261/239361 | DOI: | 10.1038/s41586-020-2873-9 | Identificadores: | doi: 10.1038/s41586-020-2873-9 issn: 1476-4687 |
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