Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/239275
Share/Export:
![]() |
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis |
Authors: | Guzmán, Fanny; Gauna, Adriana; Luna, Omar; Román, Tanya; Álvarez, Claudio; Albericio, Fernando; Cárdenas, Constanza | Issue Date: | 2020 | Publisher: | Springer | Citation: | Amino Acids 52: 1201- 1205 (2020) | Abstract: | Several factors have influenced the increasing presence of peptides as an important class of Active Pharmaceutical Ingredients. One is the continued development of synthetic methodologies for peptide synthesis. Herein, we investigated the Fmoc removal step, using the tea-bag strategy. In this regard, three different secondary amines: piperidine, 4-methylpiperidine, and piperazine, were evaluated. As a result of this study, 4-methyl piperidine showed to be an excellent alternative to the usually used piperidine in terms of purity and compliance with green chemistry principles as well. | Publisher version (URL): | http://dx.doi.org/10.1007/s00726-020-02883-8 | URI: | http://hdl.handle.net/10261/239275 | Identifiers: | doi: 10.1007/s00726-020-02883-8 issn: 1438-2199 |
Appears in Collections: | (IQAC) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis.docx | 20,24 kB | Microsoft Word XML | View/Open |
Review this work
Page view(s)
40
checked on May 23, 2022
Download(s)
22
checked on May 23, 2022
Google ScholarTM
Check
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.