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Title

Bacterial lipopolysaccharide antagonizes transforming growth factor β1–induced apoptosis in primary cultures of hepatocytes

AuthorsMartín-Sanz, Paloma ; Díaz-Guerra, María José; Casado, Marta CSIC ORCID ; Boscá, Lisardo CSIC ORCID CVN
Issue DateMay-1996
PublisherWiley-Blackwell
CitationHepatology 23(5): 1200-1207 (1996)
AbstractIncubation of primary cultures of fetal hepatocytes with lipopolysaccharide (LPS) elicited the expression of nitric oxide (NO) synthetase as well as antagonized the apoptotic cell death evoked by treating the cells with transforming growth factor 1 (TGF-1). In addition to LPS, exposure of the cells to chemical NO donors also protected against apoptotic cell death when assayed at concentrations in the low micromolar range. Treatment of hepatocytes with large concentrations of NO donors promoted both apoptotic and necrotic cell death. These results suggest that NO synthesis by hepatocytes might be involved in the protection against apoptotic death.
Description8 pages, 6 figures, 1 table.
Publisher version (URL)http://dx.doi.org/10.1002/hep.510230539
URIhttp://hdl.handle.net/10261/23905
DOI10.1002/hep.510230539
ISSN0270-9139
Appears in Collections:(IIBM) Artículos

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