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http://hdl.handle.net/10261/23890
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Frade López, José María | - |
dc.contributor.author | Martí, Elisa | - |
dc.contributor.author | Bovolenta, Paola | - |
dc.contributor.author | Rodríguez-Peña, Ángeles | - |
dc.contributor.author | Pérez-García, D. | - |
dc.contributor.author | Rohrer, Hermann | - |
dc.contributor.author | Edgar, David | - |
dc.contributor.author | Rodríguez-Tebar, Alfredo | - |
dc.date.accessioned | 2010-05-04T10:45:41Z | - |
dc.date.available | 2010-05-04T10:45:41Z | - |
dc.date.issued | 1996-08 | - |
dc.identifier.citation | Development 122(8): 2497-2506 (1996) | en_US |
dc.identifier.issn | 0950-1991 | - |
dc.identifier.uri | http://hdl.handle.net/10261/23890 | - |
dc.description | 10 pages, 9 figures, 1 table. | en_US |
dc.description.abstract | Insulin-like growth factor I (IGF-I) strongly stimulates the generation of differentiated neurons in cultures of neuroepithelial cells of the embryonic chick neural retina in the presence of a laminin-1 tissue culture substrate. Treatment of cultured neuroepithelial cells with IGF-I rapidly up-regulated the mRNA coding for the alpha 6 integrin subunit whereas specific reduction of alpha 6 subunit levels by treatment with an alpha 6 integrin antisense oligonucleotide resulted in reduced neuronal differentiation in vitro. Although IGF-I immunoreactivity is seen throughout the neural retina, expression of IGF-I mRNA is confined to the pigment epithelium during the period of neurogenesis in vivo. Neutralization of the endogenous IGF-I with a blocking antibody down-regulated levels of alpha 6 integrin mRNA and reduced the production of differentiated retinal neurons in vivo. These data indicate a role for IGF-I in the generation of retinal neurons mediated by the interaction of laminin with its alpha 6 integrin subunit-containing receptor. | en_US |
dc.description.sponsorship | This research was financed by grants from the DGICYT (Ministry of Science of Spain, no. PB93-0124), Regional Governments of Madrid and Canary Islands, Spain and the European Union, Programme Science (no. SCC-CT90-0021). | en_US |
dc.format.extent | 701216 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Company of Biologists | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Retina development | en_US |
dc.subject | Neuron differentiation | en_US |
dc.subject | Insulin-like growth factor I | en_US |
dc.subject | Integrin subunit alpha 6 | en_US |
dc.subject | Chicks | en_US |
dc.title | Insulin-like growth factor-I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit | en_US |
dc.type | artículo | en_US |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dev.biologists.org/content/122/8/2497.long | en_US |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IC) Artículos (IIBM) Artículos |
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