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Título: | Insulin-like growth factor-I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit |
Autor: | Frade López, José María CSIC ORCID ; Martí, Elisa CSIC ORCID ; Bovolenta, Paola CSIC ORCID; Rodríguez-Peña, Ángeles CSIC ORCID; Pérez-García, D.; Rohrer, Hermann; Edgar, David; Rodríguez-Tebar, Alfredo CSIC | Palabras clave: | Retina development Neuron differentiation Insulin-like growth factor I Integrin subunit alpha 6 Chicks |
Fecha de publicación: | ago-1996 | Editor: | Company of Biologists | Citación: | Development 122(8): 2497-2506 (1996) | Resumen: | Insulin-like growth factor I (IGF-I) strongly stimulates the generation of differentiated neurons in cultures of neuroepithelial cells of the embryonic chick neural retina in the presence of a laminin-1 tissue culture substrate. Treatment of cultured neuroepithelial cells with IGF-I rapidly up-regulated the mRNA coding for the alpha 6 integrin subunit whereas specific reduction of alpha 6 subunit levels by treatment with an alpha 6 integrin antisense oligonucleotide resulted in reduced neuronal differentiation in vitro. Although IGF-I immunoreactivity is seen throughout the neural retina, expression of IGF-I mRNA is confined to the pigment epithelium during the period of neurogenesis in vivo. Neutralization of the endogenous IGF-I with a blocking antibody down-regulated levels of alpha 6 integrin mRNA and reduced the production of differentiated retinal neurons in vivo. These data indicate a role for IGF-I in the generation of retinal neurons mediated by the interaction of laminin with its alpha 6 integrin subunit-containing receptor. | Descripción: | 10 pages, 9 figures, 1 table. | Versión del editor: | http://dev.biologists.org/content/122/8/2497.long | URI: | http://hdl.handle.net/10261/23890 | ISSN: | 0950-1991 |
Aparece en las colecciones: | (IC) Artículos (IIBM) Artículos |
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