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CD300a identifies a CD4(+)memory T cell subset with a higher susceptibility to HIV-1 infection

AuthorsVitallé, Joana; Tarancón-Díez, Laura; Jiménez-León, María Reyes; Terrén, Íñigo; Orrantia, Ane; Roca-Oporto, Cristina; López-Cortés, Luis F. CSIC; Ruiz-Mateos, Ezequiel; Zenarruzabeitia, Olatz; Borrego, Francisco
Issue Date1-Jul-2020
PublisherLippincott Williams & Wilkins
Wolters Kluwer
CitationAIDS - Official Journal of the International AIDS Society 34(8): 1249-1252 (2020)
AbstractHuman CD300a is known to promote the infection by dengue and other enveloped viruses and is overexpressed on CD4+ T cells from HIV-1-infected patients. We found that infected CD4+RA− T cells from untreated HIV-1-infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA− T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a− cells. CD300a might represent a biomarker of susceptibility to HIV-1 infection on memory CD4+ T lymphocytes.
Publisher version (URL)http://dx.doi.org/10.1097/QAD.0000000000002544
Identifiersdoi: 10.1097/QAD.0000000000002544
issn: 0269-9370
e-issn: 1473-5571
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