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Título: | Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress |
Autor: | Brea, Rocío CSIC; Valdecantos, Pilar; Rada, Patricia CSIC ORCID; Alén, Rosa CSIC ORCID; García-Monzón, Carmelo; Boscá, Lisardo CSIC ORCID CVN ; Fuertes-Agudo, Marina CSIC ORCID; Casado, Marta CSIC ORCID ; Martín-Sanz, Paloma CSIC ORCID ; Valverde, Ángela M. CSIC ORCID | Palabras clave: | APAP Aging Inflammation Liver Oxidative stress |
Fecha de publicación: | 29-mar-2021 | Editor: | Impact Journals | Citación: | Aging 13(6):7800-7827 (2021) | Resumen: | The liver exhibits a variety of functions that are well-preserved during aging. However, the cellular hallmarks of aging increase the risk of hepatic alterations and development of chronic liver diseases. Acetaminophen (APAP) is a first choice for relieving mild-to-moderate pain. Most of the knowledge about APAP-mediated hepatotoxicity arises from acute overdose studies due to massive oxidative stress and inflammation, but little is known about its effect in age-related liver inflammation after chronic exposure. Our results show that chronic treatment of wild-type mice on the B6D2JRcc/Hsd genetic background with APAP at an infratherapeutic dose reduces liver alterations during aging without affecting body weight. This intervention attenuates age-induced mild oxidative stress by increasing HO-1, MnSOD and NQO1 protein levels and reducing ERK1/2 and p38 MAPK phosphorylation. More importantly, APAP treatment counteracts the increase in Cd8+ and the reduction in Cd4+ T lymphocytes observed in the liver with age. This response was also found in peripheral blood mononuclear cells. In conclusion, chronic infratherapeutic APAP treatment protects mice from age-related liver alterations by attenuating oxidative stress and inflammation. | Descripción: | 28 páginas, 7 figuras, 2 tablas | Versión del editor: | https://dx.doi.org/10.18632/aging.202884 | URI: | http://hdl.handle.net/10261/238682 | DOI: | 10.18632/aging.202884 | E-ISSN: | 1945-4589 |
Aparece en las colecciones: | (IBV) Artículos (IIBM) Artículos (IBV) Comunicaciones congresos |
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2021 Aging 13-7800.pdf | 2,94 MB | Adobe PDF | Visualizar/Abrir |
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