Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/238682
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress

AutorBrea, Rocío CSIC; Valdecantos, Pilar; Rada, Patricia CSIC ORCID; Alén, Rosa CSIC ORCID; García-Monzón, Carmelo; Boscá, Lisardo CSIC ORCID CVN ; Fuertes-Agudo, Marina CSIC ORCID; Casado, Marta CSIC ORCID ; Martín-Sanz, Paloma CSIC ORCID ; Valverde, Ángela M. CSIC ORCID
Palabras claveAPAP
Aging
Inflammation
Liver
Oxidative stress
Fecha de publicación29-mar-2021
EditorImpact Journals
CitaciónAging 13(6):7800-7827 (2021)
ResumenThe liver exhibits a variety of functions that are well-preserved during aging. However, the cellular hallmarks of aging increase the risk of hepatic alterations and development of chronic liver diseases. Acetaminophen (APAP) is a first choice for relieving mild-to-moderate pain. Most of the knowledge about APAP-mediated hepatotoxicity arises from acute overdose studies due to massive oxidative stress and inflammation, but little is known about its effect in age-related liver inflammation after chronic exposure. Our results show that chronic treatment of wild-type mice on the B6D2JRcc/Hsd genetic background with APAP at an infratherapeutic dose reduces liver alterations during aging without affecting body weight. This intervention attenuates age-induced mild oxidative stress by increasing HO-1, MnSOD and NQO1 protein levels and reducing ERK1/2 and p38 MAPK phosphorylation. More importantly, APAP treatment counteracts the increase in Cd8+ and the reduction in Cd4+ T lymphocytes observed in the liver with age. This response was also found in peripheral blood mononuclear cells. In conclusion, chronic infratherapeutic APAP treatment protects mice from age-related liver alterations by attenuating oxidative stress and inflammation.
Descripción28 páginas, 7 figuras, 2 tablas
Versión del editorhttps://dx.doi.org/10.18632/aging.202884
URIhttp://hdl.handle.net/10261/238682
DOI10.18632/aging.202884
E-ISSN1945-4589
Aparece en las colecciones: (IBV) Artículos
(IIBM) Artículos
(IBV) Comunicaciones congresos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
2021 Aging 13-7800.pdf2,94 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

1
checked on 15-mar-2024

WEB OF SCIENCETM
Citations

1
checked on 28-feb-2024

Page view(s)

119
checked on 18-mar-2024

Download(s)

248
checked on 18-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.