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Título

Molecular analysis of the 21-kb bacteriocin-encoding plasmid pEF1 from Enterococcus faecium 6T1a

AutorRuiz-Barba, José Luis ; Caballero-Guerrero, Belén ; Maldonado-Barragán, Antonio ; Jiménez Díaz, Rufino
Palabras claveBacteriocinogenic plasmid
Plasmid stability
Enterococcus faecium
Nucleotide sequence
Annotation
Fecha de publicaciónmar-2007
CitaciónPlasmid 57(2): 175-181 (2007)
ResumenThe complete 21,344-bp DNA sequence of the bacteriocin-encoding plasmid pEF1 from Enterococcus faecium 6T1a was determined. Thirty-four putative open reading frames which could code for proteins longer than 42 amino acids were found. Those included the structural genes encoding for the previously described bacteriocins enterocin I and J (also named as enterocins L50A and L50B). After comparison to sequences in public databases, analysis of the gene organization of pEF1 suggests a modular structure with three diVerent functional domains: the replication region, the bacteriocin region and the mobilization plus UV-resistance region. This genetic mosaic structure most probably evolved through recombination events promoted by transposable elements. The hypothesis that the bacteriocin cluster on pEF1 could act as a functional plasmid stabilization module in E. faecium 6T1a is discussed.
Versión del editorhttp://dx.doi.org/10.1016/j.plasmid.2006.06.003
URIhttp://hdl.handle.net/10261/23855
DOI10.1016/j.plasmid.2006.06.003
ISSN0147-619X
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