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http://hdl.handle.net/10261/238317
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Yeregui, Elena | es_ES |
dc.contributor.author | Viladés, Consuelo | es_ES |
dc.contributor.author | Domingo, Pere | es_ES |
dc.contributor.author | Ceausu, Andra | es_ES |
dc.contributor.author | Pacheco, Yolanda M. | es_ES |
dc.contributor.author | Veloso, Sergi | es_ES |
dc.contributor.author | Inciarte, Alexy | es_ES |
dc.contributor.author | Vidal-González, Judit | es_ES |
dc.contributor.author | Peraire, Maria | es_ES |
dc.contributor.author | Perpiñán, Carles | es_ES |
dc.contributor.author | Falcó, Vicenç | es_ES |
dc.contributor.author | Masip, Jenifer | es_ES |
dc.contributor.author | Alba, Verónica | es_ES |
dc.contributor.author | Vargas, Montserrat | es_ES |
dc.contributor.author | Martí, Anna | es_ES |
dc.contributor.author | Reverté, Laia | es_ES |
dc.contributor.author | Mallolas, Josep | es_ES |
dc.contributor.author | Vidal, Francesc | es_ES |
dc.contributor.author | Peraire, Joaquim | es_ES |
dc.contributor.author | Rull, Anna | es_ES |
dc.date.accessioned | 2021-04-15T12:40:07Z | - |
dc.date.available | 2021-04-15T12:40:07Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | EBioMedicine 62: 103077 (2020) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/238317 | - |
dc.description | © 2020 The Authors. | - |
dc.description.abstract | [Background]: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+ T-cell turnover. | - |
dc.description.abstract | [Methods]: We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractalkine/CX3CL1, MCP-1/CCL2, MIP-α/CCL3, MIP-β/CCL4 and RANTES/CCL5, and we estimated their association with CXCL12, CX3CR1, CCR2, CCL5 and CCR5 single nucleotide polymorphisms (SNPs) to investigate multiple chemokine-chemokine receptor signatures associated with immune dysregulation preceding poor immune recovery. | - |
dc.description.abstract | [Findings]: The circulating concentrations and gene expression patterns of SDF-1/CXCL12 (CXCL12 rs1801157) and MCP-1/CCL2 (CCR2 rs1799864_814) were associated with immune recovery status. CCR2 rs1799864_814 and CCR5 rs333_814 (Δ32) determine the baseline plasma RANTES and MIP-α concentrations, respectively, in participants with poor immune response. | - |
dc.description.abstract | [Interpretation]: SDF-1/CXCL12 and MCP-1/CCL2 could be considered prognostic markers of immune failure despite suppressive antiretroviral therapy. The strong linkage disequilibrium (LD) between CCR2 rs1799864_814 and CCR5 rs1800024 indicated that the alleles of each gene are inherited together more often than would be expected by chance. | - |
dc.description.sponsorship | This work was supported by the Fondo de Investigacion Sanitaria [PI10/02635, PI13/0796, PI14/ 0063, PI14/0700, PI16/00503, PI17/0420, PI17/0498, PI18/01216, PI19/01337 and PI20/00326]-ISCIII-FEDER (co-funded by the European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”); Programa de Suport als Grups de Recerca AGAUR (2014SGR250, 2017SGR948); Gilead Fellowship Program GLD14/293and GLD19/00,008; and The SPANISH AIDS Research Network [RD12/0017/0005, RD16/0025/0002, RD16/0025/0006, RD16/0025/0019]-ISCIII-FEDER (Spain). FV is supported by grants from the Programa de Intensificación de Investigadores (INT20/00031)-ISCIII. PD is supported by grants from the Programa de Intensificación de Investigadores (INT19/00036)-ISCIII. YMP is supported by the Servicio Andaluz de Salud through Programa Nicolás Monardes (C-0013/17). JVG is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI19/00330″ through the program “Contratos Predoctorales de Formación en Investigación en Salud”. EY is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI20/00118″ through the program “Contratos Predoctorales de Formación en Investigación en Salud”. LR is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CD20/00105″ through the program “Sara Borrell”. AR is supported by a grant from the Acció Instrumental d'incorporació de científics i tecnòòlegs (PERIS SLT002/16/00,101), Departament de Salut, Generalitat de Catalunya, by IISPV through the project “2019/IISPV/05″ (Boosting Young Talent), by GeSIDA through the "III Premio para Jóvenes Investigadores 2019″ and by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CP19/00,146″ through the Miguel Servet Program. | - |
dc.language | eng | - |
dc.publisher | Elsevier | es_ES |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Chemokines | - |
dc.subject | Chemokine receptors | - |
dc.subject | HIV | - |
dc.subject | Poor immune recovery | - |
dc.subject | Polymorphisms variants | - |
dc.title | High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.ebiom.2020.103077 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.ebiom.2020.103077 | - |
dc.identifier.e-issn | 2352-3964 | - |
dc.date.updated | 2021-04-15T12:40:07Z | - |
dc.rights.license | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 33166788 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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