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Title

The Journey of Human Drugs from Their Design at the Bench to Their Fate in Crops

AuthorsMontemurro, Nicola; Peña-Herrera, Juan Manuel; Ginebreda Martí, Antoni CSIC ORCID; Eichhorn, Peter; Pérez, Sandra
KeywordsADME
Analytical methods
Crops
Distribution
Drug development
Drug discovery
Earthworms
Fate
Humans
Metabolism
Soil
Wetlands
Issue Date21-Aug-2020
PublisherSpringer
CitationInteraction and Fate of Pharmaceuticals in Soil-Crop Systems 3-31 (2020)
AbstractThe topic of this book is dedicated to the analysis, fate, metabolism, effects, and remediation of pharmaceutically active compounds in water-soil-biota systems. While the majority of readers are likely to already have a broad understanding of potential entry points, flows, transformation pathways, and temporary and permanent sinks of drugs in the environment, the objectives of this first chapter are fourfold: (a) to provide a concise overview of the journey a drug takes from its inception at the laboratory bench to the desk of the reviewer at the regulatory agency; (b) to understand the biological and physiological processes a drug undergoes from administration to humans – or to the animal in case of veterinary medicines – to their excretion and ultimately discharge into wastes; (c) to describe the physico-chemical space small-molecule drugs reside in as this characteristic largely governs their later environmental fate; (d) to review their presence, fate, and metabolism in crops and plants determined using innovative analytical methods; as well as (e) to evaluate the effects and remediation of drugs in crops and biota.
Publisher version (URL)https://doi.org/10.1007/698_2020_643
URIhttp://hdl.handle.net/10261/237337
DOIhttp://dx.doi.org/10.1007/698_2020_643
Appears in Collections:(IDAEA) Libros y partes de libros
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