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http://hdl.handle.net/10261/237220
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Merchante, Nicolás | es_ES |
dc.contributor.author | Rodríguez-Fernández, Miguel | es_ES |
dc.contributor.author | Figueruela, Blanca | es_ES |
dc.contributor.author | Rodríguez-Arrondo, Francisco | es_ES |
dc.contributor.author | Revollo, Boris | es_ES |
dc.contributor.author | Ibarra, Sofía | es_ES |
dc.contributor.author | Téllez, Francisco | es_ES |
dc.contributor.author | Merino, Esperanza | es_ES |
dc.contributor.author | Montero-Alonso, Marta | es_ES |
dc.contributor.author | Galindo, María José | es_ES |
dc.contributor.author | Rivero, Antonio | es_ES |
dc.contributor.author | Santos, Ignacio de los | es_ES |
dc.contributor.author | Delgado-Fernández, Marcial | es_ES |
dc.contributor.author | García-Deltoro, Miguel | es_ES |
dc.contributor.author | Vera-Méndez, Francisco Jesús | es_ES |
dc.contributor.author | García, María A. | es_ES |
dc.contributor.author | Aguirrebengoa, Koldo | es_ES |
dc.contributor.author | Portu, Joseba | es_ES |
dc.contributor.author | Ríos-Villegas, María José | es_ES |
dc.contributor.author | Villalobos, Marina | es_ES |
dc.contributor.author | Alemán-Valls, María R. | es_ES |
dc.contributor.author | Mínguez, Carlos | es_ES |
dc.contributor.author | Galera-Peñaranda, Carlos | es_ES |
dc.contributor.author | Macías Sánchez, Juan | es_ES |
dc.contributor.author | Pineda, Juan A. | es_ES |
dc.date.accessioned | 2021-04-08T09:10:28Z | - |
dc.date.available | 2021-04-08T09:10:28Z | - |
dc.date.issued | 2020-08-01 | - |
dc.identifier.citation | AIDS 34(10): 1497-1507 (2020) | es_ES |
dc.identifier.issn | 0269-9370 | - |
dc.identifier.uri | http://hdl.handle.net/10261/237220 | - |
dc.description.abstract | [Background]: Previous studies have suggested that hepatocellular carcinoma (HCC) has an aggressive presentation and a shorter survival in people with HIV (PWH). This could be due to later diagnosis or lower rates of HCC treatment, and not to HIV infection itself. | - |
dc.description.abstract | [Aim]: To assess the impact of HIV on HCC survival in hepatitis C virus (HCV)-infected patients. | - |
dc.description.abstract | [Methods]: Multicenter cohort study (1999–2018) of 342 and 135 HCC cases diagnosed in HIV/HCV-infected and HCV-monoinfected patients. Survival after HCC diagnosis and its predictors were assessed. | - |
dc.description.abstract | [Results]: HCC was at Barcelona-Clinic Liver-Cancer (BCLC) stage 0/A in 114 (33%) HIV/HCV-coinfected and in 76 (56%) HCV-monoinfected individuals (P < 0.001). Of them, 97 (85%) and 50 (68%) underwent curative therapies (P = 0.001). After a median (Q1–Q3) follow-up of 11 (3–31) months, 334 (70%) patients died. Overall 1 and 3-year survival was 50 and 31% in PWH and 69 and 34% in those without HIV (P = 0.16). Among those diagnosed at BCLC stage 0/A, 1 and 3-year survival was 94 and 66% in PWH whereas it was 90 and 54% in HIV-negative patients (P = 0.006). Independent predictors of mortality were age, BCLC stage and α-fetoprotein levels. HIV infection was not independently associated with mortality [adjusted hazard ratio (AHR) 1.57; 95% confidence interval: 0.88–2.78; P = 0.12]. | - |
dc.description.abstract | [Conclusion]: HIV coinfection has no impact on the survival after the diagnosis of HCC in HCV-infected patients. Although overall mortality is higher in HIV/HCV-coinfected patients, this seem to be related with lower rates of early diagnosis HCC in HIV-infected patients and not with HIV infection itself or a lower access to HCC therapy. | - |
dc.language | eng | - |
dc.publisher | Lippincott Williams & Wilkins | es_ES |
dc.rights | closedAccess | - |
dc.subject | Cirrhosis | - |
dc.subject | Hepatitis C virus | - |
dc.subject | Hepatocellular carcinoma | - |
dc.subject | HIV | - |
dc.subject | Liver cancer | - |
dc.title | Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1097/QAD.0000000000002578 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1097/QAD.0000000000002578 | - |
dc.identifier.e-issn | 1473-5571 | - |
dc.date.updated | 2021-04-08T09:10:28Z | - |
dc.relation.csic | Sí | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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