Please use this identifier to cite or link to this item:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invite to open peer review

H2AK121ub inArabidopsisassociates with a lessaccessible chromatin state at transcriptionalregulation hotspots

AuthorsYin, Xiaochang; Romero-Campero, Francisco J. CSIC ORCID ; Reyes, Pedro de los; Yan, Peng; Yang, Jing; Tian, Guangmei; Yang, XiaoZeng; Mo, Xiarong; Zau, Shuangshuang; Calonje, Myriam CSIC ORCID ; Zhou, Yue
Issue Date2021
PublisherNature Publishing Group
CitationNature Communications 12 (2021)
AbstractAlthough it is well established that the Polycomb Group (PcG) complexes maintain generepression through the incorporation of H2AK121ub and H3K27me3, little is known about theeffect of these modifications on chromatin accessibility, which is fundamental to understandPcG function. Here, by integrating chromatin accessibility, histone marks and expressionanalyses in differentArabidopsisPcG mutants, we show that PcG function regulates chro-matin accessibility. Wefind that H2AK121ub is associated with a less accessible but stillpermissive chromatin at transcriptional regulation hotspots. Accessibility is further reducedby EMF1 acting in collaboration with PRC2 activity. Consequently, H2AK121ub/H3K27me3marks are linked to inaccessible although responsive chromatin. In contrast, only-H3K27me3-marked chromatin is less responsive, indicating that H2AK121ub-marked hotspots arerequired for transcriptional responses. Nevertheless, despite the loss of PcG activities leads toincreased chromatin accessibility, this is not necessarily accompanied by transcriptionalactivation, indicating that accessible chromatin is not always predictive of gene expression.
Publisher version (URL)
Identifiersdoi: 10.1038/s41467-020-20614-1
issn: 2041-1723
Appears in Collections:(IBVF) Artículos

Files in This Item:
File Description SizeFormat
826194.pdf2,53 MBUnknownView/Open
Show full item record

CORE Recommender

Page view(s)

checked on Apr 22, 2024


checked on Apr 22, 2024

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons