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Título: | Gold Nanoparticles Crossing Blood-Brain Barrier Prevent HSV-1 Infection and Reduce Herpes Associated Amyloid-beta secretion |
Autor: | Rodríguez-Izquierdo, I; Serramía, María Jesús; Gómez, R.; De La Mata, F.J.; Bullido, María Jesús CSIC ORCID; Muñoz-Fernández, María Ángeles CSIC ORCID | Palabras clave: | HSV-1 gold nanoparticles Central nervous system Amyloid- peptides Neurodegeneration |
Fecha de publicación: | 7-ene-2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Journal of Clinical Medicine 9 (2020) | Resumen: | Infections caused by HSV-1 and their typical outbreaks invading the nervous system have been related to neurodegenerative diseases. HSV-1 infection may deregulate the balance between the amyloidogenic and non-amyloidogenic pathways, raising the accumulation of amyloid- peptides, one of the hallmarks in the neurodegenerative diseases. An eective treatment against both, HSV-1 infections and neurodegeneration, is a major therapeutic target. Therefore, gold nanoparticles (NPAus) have been previously studied in immunotherapy, cancer and cellular disruptions with very promising results. Our study demonstrates that a new NPAus family inhibits the HSV-1 infection in a neural-derived SK-N-MC cell line model and that this new NPAus reduces the HSV-1-induced -secretase activity, as well as amyloid- accumulation in SK-APP-D1 modifies cell line. We demonstrated that NPAuG3-S8 crosses the blood-brain barrier (BBB) and does not generate cerebral damage to in vivo CD1 mice model. The NPAuG3-S8 could be a promising treatment against neuronal HSV-1 infections and neuronal disorders related to the A peptides. | Versión del editor: | http://dx.doi.org/10.3390/jcm9010155 | URI: | http://hdl.handle.net/10261/236654 | DOI: | 10.3390/jcm9010155 | Identificadores: | doi: 10.3390/jcm9010155 issn: 2077-0383 |
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BullidoMJ_GoldNanoparticles.pdf | 1,87 MB | Adobe PDF | Visualizar/Abrir |
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