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Title

Advances in enzymatic oxyfunctionalization of aliphatic compounds

AuthorsAranda, Carmen; Carro, Juan ; González-Benjumea, Alejandro; Babot, Esteban Daniel ; Olmedo, Andrés; Linde, Dolores ; Martínez, Ángel T. ; Gutiérrez Suárez, Ana
KeywordsAlkanes
Biocatalysis
Epoxidation
Fatty acids
Hydroxylation
Oxyfunctionalization
Peroxygenases
Terpenoids
UPO
P450
Issue Date3-Feb-2021
PublisherElsevier
CitationBiotechnology Advances 107703 (2021) Article in press
AbstractSelective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as “dream biocatalysts” of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H2O2 for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. © 2021 The Authors
Description19 páginas.- 8 figuras.- 5 tablas.- 174 referencias
Publisher version (URL)http://dx.doi.org/10.1016/j.biotechadv.2021.107703
URIhttp://hdl.handle.net/10261/236621
DOI10.1016/j.biotechadv.2021.107703
ISSN0734-9750
Appears in Collections:(CIB) Artículos
(IRNAS) Artículos
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