Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/236080
Share/Export:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Tuberculosis in a Spanish cohort of children living with HIV: the CHOTIS study (Childhood HIV & TB study)

AuthorsLópez-Medina, E. M.; Sainz, Talia; Jiménez de Ory, Santiago; Mellado, Maria Jose; Gonzalez-Tome, Maria I.; Colino, Elena; Vallmanya, Teresa; Falcón Neyra, Lola; Frick, M. Antoinette; Martínez-Pérez, Julia; Andrés Andrés, A. G.; Bustillo Alonso, Matilde; Guerrero Laleona, C.; Méndez Hernández, M.; Collado, Pilar; Ramos Amador, José Tomás; Navarro Gómez, María Luisa; Santiago-García, Begoña
KeywordsHIV
cART
Co-infection
Immigration
Tuberculosis
Issue Date1-Mar-2020
PublisherIngenta Connet
CitationInternational Journal of Tuberculosis and Lung Disease 24(3): 303-309 (2020)
Abstract[Background] Tuberculosis (TB) is the leading opportunistic infection in children with human immunodeficiency virus (HIV), but is uncommon in low prevalence regions. We aim to describe the changing epidemiology and clinical presentation of TB-HIV co-infection in a cohort of HIV-infected children in Spain.
[Methods] Children diagnosed with TB between 1995 and 2016 in the paediatric HIV cohort were identified. The incidence and clinical presentation were compared in three periods: 1995–1999 (P1, before initiation of combined antiretroviral therapy, cART), 2000–2009 (P2, increase in immigration), and 2010–2016 (P3, decrease in immigration).
[Results] We included 29 TB cases among 1183 children aged <18 years (2.4%, 243/100 000 person-years). The proportion was stable in P1 and P2 (1.3%), but decreased in P3 (0.8%). The median age at TB diagnosis was 6.4 years (IQR 4–10.6); most children in P3 were aged >10 years (20% vs. 23.1% vs. 83.3%, P = 0.01). TB was diagnosed at HIV presentation in 11/29 children (37.9%). Foreign-born children accounted for respectively 0%, 8% and 67% of the total number of children in each period (P ≤ 0.0001). One third had extrapulmonary TB; four children died (13.8%).
[Conclusion] In our cohort, the incidence of TB-HIV co-infection decreased with decline in immigration. In regions with adequate cART coverage and low TB transmission, paediatric TB-HIV coinfection is uncommon, but associated with significant morbidity. Strategies for TB surveillance, diagnosis and treatment in this vulnerable population should be reinforced.
DescriptionNational Network of HIV-infected Children (CORISPE); National Pediatric TB Network (pTBred) of Spain; Translational Research Network in Pediatric Infectious Diseases (RITIP).
Publisher version (URL)http://doi.org/10.5588/ijtld.19.0237
URIhttp://hdl.handle.net/10261/236080
Identifiersdoi: 10.5588/ijtld.19.0237
issn: 1027-3719
e-issn: 1815-7920
Appears in Collections:(IBIS) Artículos

Files in This Item:
File Description SizeFormat
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

Google ScholarTM

Check


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.