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Title

A single dose of dendrimer b2t peptide vaccine partially protects pigs against foot-and-mouth disease virus infection

AuthorsCañas-Arranz, Rodrigo; Forner, Mar; Defaus, Sira; León, Patricia de CSIC ORCID; Bustos, Maria José; Torres, Elisa; Sobrino Castelló, Francisco CSIC ORCID; Blanco Lavilla, Esther CSIC ORCID; Andreu, David
KeywordsPeptide vaccine
Single dose
Amount
Pig
Issue Date10-Jun-2020
CitationVaccines 8 (2020)
AbstractFoot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals whose control relies on efficient vaccination. We have reported that dendrimer peptide BT, with two copies of FMDV B-cell epitope VP1 (136–154) linked through maleimide units to T-cell epitope 3A (21–35)], elicits potent B-and T-cell specific responses and confers solid protection in pigs to type-O FMDV challenge after two doses of peptide. Herein we now show that BT evokes specific protective immune responses after administration of a single dose of either 2 or 0.5 mg of peptide. High titers of ELISA and neutralizing antibodies against FMDV were detectable at day 15 post-immunization. Likewise, activated T cells and induced IFN-γ response to in vitro recall with FMDV peptides were also detected by the same day. Further, in 70% of BT-vaccinated pigs, full protection—no clinical signs of disease—was observed upon virus challenge at day 25 post-immunization. These results strengthen the potential of BT as a safe, cost-effective candidate vaccine conferring adequate protection against FMDV with a single dose. The finding is particularly relevant to emergency scenarios permitting only a single shot immunization.
Publisher version (URL)http://dx.doi.org/10.3390/vaccines8010019
URIhttp://hdl.handle.net/10261/235529
DOI10.3390/vaccines8010019
Identifiersdoi: 10.3390/vaccines8010019
issn: 2076-393X
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