Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/235459
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Breast cancer biomarker detection through the photoluminescence of epitaxial monolayer MoS2 flakes |
Autor: | Catalán-Gómez, Sergio; Briones, María; Cortijo-Campos, Sandra; García-Mendiola, Tania; Andrés, Alicia de CSIC ORCID; Garg, Sourav; Kung, Patrick; Lorenzo, Encarnación; Pau, José Luis; Redondo-Cubero, Andrés | Palabras clave: | Optical biosensors MoS2 monolayer Breast cancer Biomarkers Photoluminescence |
Fecha de publicación: | 29-sep-2020 | Editor: | Nature Publishing Group | Citación: | Scientific Reports 10 (2020) | Resumen: | In this work we report on the characterization and biological functionalization of 2D MoS flakes, epitaxially grown on sapphire, to develop an optical biosensor for the breast cancer biomarker miRNA21. The MoS flakes were modified with a thiolated DNA probe complementary to the target biomarker. Based on the photoluminescence of MoS, the hybridization events were analyzed for the target (miRNA21c) and the control non-complementary sequence (miRNA21nc). A specific redshift was observed for the hybridization with miRNA21c, but not for the control, demonstrating the biomarker recognition via PL. The homogeneity of these MoS platforms was verified with microscopic maps. The detailed spectroscopic analysis of the spectra reveals changes in the trion to excitation ratio, being the redshift after the hybridization ascribed to both peaks. The results demonstrate the benefits of optical biosensors based on MoS monolayer for future commercial devices. | Versión del editor: | http://dx.doi.org/10.1038/s41598-020-73029-9 | URI: | http://hdl.handle.net/10261/235459 | DOI: | 10.1038/s41598-020-73029-9 | ISSN: | 2045-2322 |
Aparece en las colecciones: | (ICMM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
CATALÁN-GÓMEZ_brest cancer_Scientific Reports_2020.pdf | 3,62 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
9
checked on 11-abr-2024
SCOPUSTM
Citations
34
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
25
checked on 26-feb-2024
Page view(s)
76
checked on 24-abr-2024
Download(s)
61
checked on 24-abr-2024