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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/235151
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Title: 

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

Authors: Urdinguio, Rocío G. CSIC ORCID; López, Virginia CSIC ORCID; Bayón, Gustavo F.; Díaz de la Guardia, Rafael; Sierra, Marta I.; García-Toraño, Estela; Pérez, Raúl F. CSIC ORCID; García, María G.; Carella, Antonella; Pruneda, Patricia C.; Prieto López, Cristina CSIC ORCID ; Dmitrijeva, Marija; Santamarina-Ojeda, Pablo; Belmonte, Thalia; Mangas, Cristina; Diaconu, Elena; Ferrero, Cecilia; Tejedor, Juan Ramón CSIC ORCID ; Fernández-Morera, Juan L.; Bravo, Cristina; Bueno, Clara; Sanjuan-Pla, Alejandra; Rodríguez López, Ramón María; Suárez-Álvarez, Beatriz; López-Larrea, Carlos; Bernal, Teresa; Colado, Enrique; Balbín, Milagros; García-Suarez, Olivia; Chiara, María-Dolores; Sáenz-de-Santa-María, Inés; Rodríguez Hernández, Francisco José CSIC ORCID; Pando-Sandoval, Ana; Rodrigo, Luis; Santos, Laura; Salas, Ana; Vallejo-Díaz, Jesús; Carrera, Ana C.; Rico, Daniel; Hernández-López, Inmaculada; Vayá, Amparo; Ricart, José M.; Seto, Edward; Sima-Teruel, Núria; Vaquero, Alejandro CSIC ORCID; Valledor, Luis; Cañal, María Jesús; Pisano, David; Graña-Castro, Osvaldo; Thomas, Tim; Voss, Anne K.; Menéndez, Pablo; Villar-Garea, Ana; Deutzmann, Rainer; Fernández, Agustín F. CSIC ORCID; Fraga, Mario F. CSIC ORCID
Issue Date: 19-Dec-2018
Abstract: Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death.
Description: Supplementary data files corresponding to manuscript: Urdinguio, Lopez et al.
Publisher version (URL): https://doi.org/10.5281/zenodo.2425053
URI: http://hdl.handle.net/10261/235151
DOI: 10.20350/digitalCSIC/13821
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Supplementary Table S9.xlsx15,91 kBMicrosoft Excel XMLView/Open
Supplementary Table S8.xlsx252,02 kBMicrosoft Excel XMLView/Open
Supplementary Table S7.xlsx313,79 kBMicrosoft Excel XMLView/Open
Supplementary Table S6.xlsx1,66 MBMicrosoft Excel XMLView/Open
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Supplementary Table S10a.xlsx315,46 kBMicrosoft Excel XMLView/Open
Supplementary Table S1.xlsx12,78 kBMicrosoft Excel XMLView/Open
Scripts_and_chipseq_data_H4K16ac_manuscript.tar.gz2,78 GBUnknownView/Open
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