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Antidepressant-like effect and molecular mechanism of action of cannabidiol in the lipopolysaccharide model of depression in mice

AuthorsFlorensa-Zanuy, Eva; Architravo, Annamaria; Adell, Albert CSIC ORCID ; Garro-Martínez, Emilio; Castro, Elena CSIC ORCID; Díaz, Álvaro CSIC ORCID; Pazos, Ángel CSIC ORCID; Pilar-Cuéllar, Fuencisla CSIC ORCID
KeywordsMood disorders
Neuro-inflammatory/ auto-immune
Issue Date14-Sep-2020
Citation33rd ECNP Congress Virtual (2020)
AbstractMajor Depression is an incapacitating disease spread worldwide. As its etiology is still unknown, some hypotheses have been postulated, being the neuro-inflammatory one of the most recent. The current treatment for depression is far from optimal and there is an urgent need to find fast-acting drugs with fewer side effects. In this regard, cannabidiol (CBD), the major non-psychotropic component of , appears as a promising antidepressant drug. We have evaluated CBD’s behavioural and molecular effects in a neuro-inflammatory model of depression induced by lipopolysaccharide (LPS).
DescriptionResumen del trabajo presentado en el 33rd ECNP Congress Virtual, celebrado en modalidad virtual del 12 al 15 de septiembre de 2020.
Appears in Collections:(IBBTEC) Comunicaciones congresos

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