Please use this identifier to cite or link to this item:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment

AuthorsVendrell-Criado, V.; Angulo-Pachón, C.A.; Miravet, Juan F.; Galindo, Francisco; Miranda, M. A.; Jiménez, M. Consuelo
Issue DateJan-2020
PublisherElsevier BV
CitationJournal of Photochemistry and Photobiology B: Biology 202: 111686 (2020)
AbstractIn this work, a molecular hydrogel made of gelator (S)-4-((3-methyl-1-(nonylamino)-1-oxobutan-2-yl)amino)-4-oxobutanoic acid (SVN) has been employed as soft container to modify the photochemical and photophysical behavior of the antipsychotic drug cyamemazine (CMZ). The interaction of CMZ with the gel network has been evidenced by fluorescence spectroscopy through a hypsochromic shift of the emission band (from λ = 521 nm in solution to λ = 511 nm in the gel) and an increase of the fluorescence lifetime (5.6 ns in PBS vs. 7.2 ns in the gel). In the laser flash photolysis experiments on CMZ/SVN systems, the CMZ triplet excited state (CMZ*), monitored at λ = 320 nm, has been more efficiently generated and became much longer-lived than in solution (2.7 μs vs. 0.7 μs); besides, photochemical ionization leading to the radical cation CMZ was disfavored. In the steady-state experiments, photooxidation of CMZ to afford the N,S-dioxide derivative CMZ-SONO has been retarded in the gel, which provides a more lipophilic and constrained microenvironment. Both the photophysical properties and the photoreactivity are in agreement with CMZ located in a less polar domain when entrapped in the supramolecular gel, as result of the interaction of the drug with the fibers of the supramolecular SVN gel.
Publisher version (URL)
Identifiersissn: 1873-2682
Appears in Collections:(ITQ) Artículos

Files in This Item:
File Description SizeFormat
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Page view(s)

checked on Jan 28, 2022


checked on Jan 28, 2022

Google ScholarTM


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.