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Título

Down-regulation of Glial Fibrillary Acidic Protein (GFAP) during the development of a marine fish (Dentex dentex L.)

AutorBusquets, Xavier; Morales-Nin, Beatriz
Palabras claveDentex dentex
Glia
Glial fibrillary acidic protein
Immunoblot
Western blot
Marine fish development
Fecha de publicación30-dic-1998
EditorConsejo Superior de Investigaciones Científicas (España)
CitaciónScientia Marina 62(4): 357-360 (1998)
ResumenA band of approximately 52-53 kDa, corresponding to glial fibrillary acidic protein (GFAP) was detected by immunoblot techniques in brain tissue of a marine fish (Dentex dentex L). The aim of this study was to quantify the density of GFAP during the life cycle of a marine fish in the wild. The levels of GFAP immunoreactivity were determined at two different stages of development: juvenile (body weight range: 180-360 g) and sexually developing-mature specimens (body weight range: 2329-5550 g) from a natural population in the Western Mediterranean Sea. Our results indicated a negative correlation between the immunoreactivity of GFAP and weight in the sexually developing-mature group of fishes (r=-0.785, p<0.05, n=8). These findings might be of relevance in understanding the role of GFAP in the development of the central nervous system and demonstrate that GFAP down-regulation in D. dentex brain tissue during development is a natural physiological phenomenon.
Descripción4 pages, 2 figures, 1 table.
Versión del editorhttp://dx.doi.org/10.3989/scimar.1998.62n4357
URIhttp://hdl.handle.net/10261/23381
DOI10.3989/scimar.1998.62n4357
ISSN0214-8358 (Print)
1886-8134 (Online)
ISMN10.3989/scimar.1998.62n4357
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