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Título: | The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility |
Autor: | Sánchez-Huertas, Carlos CSIC ORCID; Bonhomme, Marion; Falco, Amandine; Fagotto-Kaufmann, Christine; Haren, Jeffrey van; Jeanneteau, Freddy; Galjart, Niels; Debant, Anne; Boudeau, Jérôme | Fecha de publicación: | 2020 | Citación: | 17th Meeting of the Spanish Society for Developmental Biology (2020) | Resumen: | The microtubule plus-end tracking proteins (+TIPs) are central players in the coordination between the microtubules (MT) and actin network in the growth cone (GC) during axon guidance. The +TIP Navigator-1 (NAV1) is expressed in the developing nervous system, yet its neuronal functions remain poorly elucidated. Here, we report that NAV1 controls the GC dynamics in cortical axons and it is required for axon turning towards a gradient of netrin-1. NAV1 accumulates in the peripheral domain of axonal GCs and is able to bind actin filaments (F-actin) and microtubules in vitro. Indeed, we found that NAV1 binds MTs independently of EB1 and crosslinks non-polymerizing MT plus-ends to actin filaments in axonal GCs. Therefore, NAV1 prevents MT depolymerization in the F-actin-rich areas by stabilizing the non-growing MT plus-ends. Our findings pinpoint NAV1 as a new key player in the actin-MT crosstalk, that promotes MT persistence within the GC periphery and controls GC steering. Additionally, we present data assigning to NAV1 a role in the radial migration of cortical projection neurons in vivo. | Descripción: | Trabajo presentado al 17th Meeting of the Spanish Society for Developmental Biology (SEBD), celebrado de forma virtual del 18 al 20 de noviembre de 2020. | URI: | http://hdl.handle.net/10261/232787 |
Aparece en las colecciones: | (IN) Comunicaciones congresos |
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83. P019_Carlos_Sanchez-Huertas.pdf | 2,9 MB | Adobe PDF | Visualizar/Abrir |
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