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Title

Methicillin-resistant staphylococcus aureus in hospitals: Latest trends and treatments based on bacteriophages

AuthorsÁlvarez, Andrea; Fernández, Lucía; Gutiérrez, Diana CSIC ORCID; Iglesias, Beatriz; Rodríguez González, Ana CSIC ORCID; García Suárez, María Pilar CSIC ORCID
KeywordsStaphylococcus aureus
HA-MRSA
CA-MRSA
LA-MRSA
Antibiotic resistance
Soft-tissue infections
Osteomyelitis
Endocarditis
Phage therapy
Endolysins
Bacteriophage therapy
Bacteriophages
Endolysin
Issue Date22-Nov-2019
PublisherAmerican Society for Microbiology
CitationJournal of Clinical Microbiology 57: e01006-19 (2019)
AbstractEven though antibiotic resistance in bacteria is a natural phenomenon, the alarming increase in pathogenic bacteria refractory to a wide range of antimicrobials is attracting attention worldwide. Indeed, the World Health Organization (WHO) has recently published a list of priority pathogens for which new antimicrobial alternatives are urgently needed. Among these pathogens, methicillin-resistant Staphylococcus aureus (MRSA) strains are perhaps the best known by the general public. In addition to its potential to acquire antibiotic resistance, S. aureus can produce a large number of virulence factors, such as hemolysins, enterotoxins, and proteases, and exhibits the ability to form biofilms as well as to evolve into different clones that can spread and colonize new environments. This review provides a brief overview of the latest options in antibacterial therapies, mainly focusing on phage therapy. In this regard, the current stage of research about antimicrobial compounds based on bacteriophages and endolysins against MRSA infections is shown and discussed.
Publisher version (URL)https://doi.org/10.1128/JCM.01006-19
URIhttp://hdl.handle.net/10261/232113
DOIhttp://dx.doi.org/10.1128/JCM.01006-19
ISSN0095-1137
E-ISSN1098-660X
Appears in Collections:(IPLA) Artículos
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