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Título

Interaction of arginine-based cationic surfactants with membranes. An experimental and molecular simulation study

AutorAlmeida, Joao A. S.; Morán, María del Carmen; Infante, María Rosa; Pais, Alberto A. C. C.
Palabras claveArginine-based cationic surfactants
DPPC liposomes
Membrane organization
Fecha de publicación24-jun-2009
EditorArkat USA
CitaciónARKIVOC : free online journal of organic chemistry 2010(5): 34-50 (2010)
ResumenThe effect of two arginine-based cationic surfactants, arginine N-lauroyl amide dihydrochloride and arginine O-lauroyl ester dihydrochloride, upon dipalmitoylphosphatidylcholine liposomes, is addressed in this work. Some aspects concerning the synthesis of these surfactants are also presented in some detail. Differential scanning calorimetry, as well as fluorescence anisotropy using several probes, is used to assess the relative effects on the lipid model membranes. In spite of the structural similarity among these molecules, which differ only by the group that connects the polar head to the tail, experimental results suggest differences in their behavior. Molecular dynamics simulation provides significant insight into the molecular mechanism that governs this interaction. A rationale is provided in terms of lipid-surfactant hydrogen bonding and the consequent positioning of the surfactant molecule within the bilayer.
Descripción17 pages, 10 figures, 2 tables.-- Issue title: "Issue in Honor of Prof. António M. d’A. Rocha Gonçalves".
Versión del editorwww.arkat-usa.org/get-file/29234
URIhttp://hdl.handle.net/10261/23176
ISSN1551-7004 (Print)
1551-7012 (Online)
Aparece en las colecciones: (IQAC) Artículos
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