Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/230775
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Title

Multi-meridian corneal imaging of air-puff induced deformation for improved detection of biomechanical abnormalities

AuthorsCuratolo, A.; Birkenfeld, J.; Martínez-Enríquez, Eduardo CSIC ORCID; Germann, James CSIC; Muralidharan, Geethika; Palací, J.; Pascual, Daniel CSIC ORCID; Eliasy, A.; Abass, A.; Solarski, J.; Karnowski, K.; Wojtkowski, M.; Elsheikh, A.; Marcos, Susana CSIC ORCID
Issue Date1-Nov-2020
PublisherOptical Society of America
CitationBiomedical Optics Express 11: 6337-6355 (2020)
AbstractCorneal biomechanics play a fundamental role in the genesis and progression of corneal pathologies, such as keratoconus; in corneal remodeling after corneal surgery; and in affecting the measurement accuracy of glaucoma biomarkers, such as the intraocular pressure (IOP). Air-puff induced corneal deformation imaging reveals information highlighting normal and pathological corneal response to a non-contact mechanical excitation. However, current commercial systems are limited to monitoring corneal deformation only on one corneal meridian. Here, we present a novel custom-developed swept-source optical coherence tomography (SSOCT) system, coupled with a collinear air-puff excitation, capable of acquiring dynamic corneal deformation on multiple meridians. Backed by numerical simulations of corneal deformations, we propose two different scan patterns, aided by low coil impedance galvanometric scan mirrors that permit an appropriate compromise between temporal and spatial sampling of the corneal deformation profiles. We customized the air-puff module to provide an unobstructed SSOCT field of view and different peak pressures, air-puff durations, and distances to the eye. We acquired multi-meridian corneal deformation profiles (a) in healthy human eyes in vivo, (b) in porcine eyes ex vivo under varying controlled IOP, and (c) in a keratoconus-mimicking porcine eye ex vivo. We detected deformation asymmetries, as predicted by numerical simulations, otherwise missed on a single meridian that will substantially aid in corneal biomechanics diagnostics and pathology screening.
Description19 pags., 10 figs., 2 tabs.
Publisher version (URL)http://dx.doi.org/10.1364/BOE.402402
URIhttp://hdl.handle.net/10261/230775
Identifiersdoi: 10.1364/BOE.402402
issn: 2156-7085
Appears in Collections:(CFMAC-IO) Artículos

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