Please use this identifier to cite or link to this item:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

A dataset for the analysis of antibody response to glycan alpha-Gal in individuals with immune-mediated disorders [version 1; peer review: 1 approved]

AuthorsFuente, José de la CSIC ORCID ; Urra, José Miguel; Contreras, Marinela CSIC ORCID; Pacheco, Iván CSIC; Ferreras-Colino, Elisa CSIC ORCID; Doncel-Pérez, Ernesto CSIC ORCID; Fernández de Mera, Isabel G.; Villar, Margarita CSIC ORCID; Cabrera, Carmen M.; Gómez Hernando, Cesar; Vargas Baquero, Eduardo; Blanco García, Javier; Rodríguez Gómez, Javier; Velayos Galán, Alberto; Feo Brito, Francisco; Gómez Torrijos, Elisa; Cabezas-Cruz, Alejandro CSIC ORCID; Gortázar, Christian CSIC ORCID
KeywordsAlpha gal
Immune response
Guillain-Barré syndrome
Issue Date2021
CitationF1000Research 9: 1366 (2021)
AbstractHumans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response mediated by anti-α-Gal IgM/IgG/IgA antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can develop the alpha-Gal syndrome (AGS), a recently diagnosed disease mediated by anti-α-Gal IgE antibodies and associated with allergic reactions to mammalian meat consumption and tick bites. However, the anti-α-Gal antibody response may be associated with other immune-mediated disorders such as those occurring in patients with COVID-19 and Guillain-Barré syndrome (GBS). Here, we provide a dataset (209 entries) on the IgE/IgM/IgG/IgA anti-α-Gal antibody response in healthy individuals and patients diagnosed with AGS, tick-borne allergies, GBS and COVID-19. The data allows correlative analyses of the anti-α-Gal antibody response with factors such as patient and clinical characteristics, record of tick bites, blood group, age and sex. These analyses could provide insights into the role of anti-α-Gal antibody response in disease symptomatology and possible protective mechanisms.
Publisher version (URL)
Appears in Collections:(IREC) Artículos
(PTI Salud Global) Colección Especial COVID-19

Files in This Item:
File Description SizeFormat
datasetappro.pdf1,15 MBAdobe PDFThumbnail
Show full item record
Review this work

Page view(s)

checked on Jun 7, 2023


checked on Jun 7, 2023

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons