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Título: | The chaperonin CCT controls T cell receptor–driven 3D configuration of centrioles |
Autor: | Martín-Cófreces, Noa Beatriz CSIC ORCID; Chichón, Javier; Calvo, E.; Torralba, D.; Bustos-Moran, E.; Dosil, S. G.; Rojas-Gomez, A.; Bonzón-Kulichenko, Elena CSIC ORCID; Lopez, J. A.; Oton, Joaquin; Sorrentino, A.; Zabala, Juan Carlos; Vernos, I.; Vázquez, J.; Valpuesta, José M. CSIC ORCID ; Sánchez-Madrid, Francisco | Fecha de publicación: | 2-dic-2020 | Editor: | American Association for the Advancement of Science | Citación: | Science Advances 6(49): eabb7242 (2020) | Resumen: | T lymphocyte activation requires the formation of immune synapses (IS) with antigen-presenting cells. The dynamics of membrane receptors, signaling scaffolds, microfilaments, and microtubules at the IS determine the potency of T cell activation and subsequent immune response. Here, we show that the cytosolic chaperonin CCT (chaperonin-containing TCP1) controls the changes in reciprocal orientation of the centrioles and polarization of the tubulin dynamics induced by T cell receptor in T lymphocytes forming an IS. CCT also controls the mitochondrial ultrastructure and the metabolic status of T cells, regulating the de novo synthesis of tubulin as well as posttranslational modifications (poly-glutamylation, acetylation, Δ1 and Δ2) of αβ-tubulin heterodimers, fine-tuning tubulin dynamics. These changes ultimately determine the function and organization of the centrioles, as shown by three-dimensional reconstruction of resting and stimulated primary T cells using cryo-soft x-ray tomography. Through this mechanism, CCT governs T cell activation and polarity. | Descripción: | © 2020 The Authors. | Versión del editor: | http://dx.doi.org/10.1126/sciadv.abb7242 | URI: | http://hdl.handle.net/10261/229933 | DOI: | 10.1126/sciadv.abb7242 | E-ISSN: | 2375-2548 |
Aparece en las colecciones: | (CNB) Artículos |
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