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Título: | Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation |
Autor: | Ávila-Gálvez, María Ángeles; Giménez-Bastida, J. A. CSIC ORCID CVN ; González-Sarrías, Antonio CSIC ORCID; Espín de Gea, Juan Carlos CSIC ORCID | Fecha de publicación: | 1-jun-2019 | Editor: | Royal Society of Chemistry (UK) | Citación: | Food & function 10(6): 3135-3141 (2019) | Resumen: | Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli. | Versión del editor: | http://dx.doi.org/10.1039/c9fo00298g | URI: | http://hdl.handle.net/10261/229509 | DOI: | 10.1039/c9fo00298g | Identificadores: | doi: 10.1039/c9fo00298g issn: 2042-6496 e-issn: 2042-650X |
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Tissue_deconjugation_urolithin.pdf | 751,85 kB | Adobe PDF | Visualizar/Abrir |
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