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Título: | A Randomized, Double-Blind, Placebo-Controlled Trial (TAURCAT Study) of Citrate Lock Solution for Prevention of Endoluminal Central Venous Catheter Infection in Neutropenic Hematological Patients |
Autor: | Gudiol, Carlota; Arnan, Montserrat; Aguilar Guisado, Manuela CSIC ORCID; Royo-Cebrecos, Cristina; Sánchez-Ortega, Isabel; Montero, Isabel CSIC ORCID ; Martín-Gandul, Cecilia CSIC ORCID; Laporte-Amargós, Júlia; Albasanz-Puig, Adaia; Nicolae, Sermed; Perayre, Maria; Berbel, Dàmaris; Tebé, Cristian; Riera, Judith; Sureda, Anna; Cisneros, José Miguel CSIC ORCID; Carratalà, Jordi | Palabras clave: | Antibiotic lock technique Cancer Catheter infection Catheter-related bacteremia Catheter-related bloodstream infection Lock technique Neutropenia Prevention Taurolidine |
Fecha de publicación: | 27-ene-2020 | Editor: | American Society for Microbiology | Citación: | Antimicrobial Agents and Chemotherapy 64: e01521-19 (2020) | Resumen: | Infection of long-term central venous catheters (CVCs) remains a challenge in the clinical management of cancer patients. We aimed to determine whether a lock solution with taurolidine-citrate-heparin would be more effective than placebo for preventing nontunneled CVC infection in high-risk neutropenic hematologic patients. We performed a prospective, multicenter, randomized (1:1), double-blind, parallel, superiority, placebo-controlled trial involving 150 hematological patients with neutropenia carrying nontunneled CVCs who were assigned to receive CVC lock solution with taurolidine-citrate-heparin or heparin alone. The primary endpoint was bacterial colonization of the CVC hubs. Secondary endpoints were the incidence of catheter-related bloodstream infection (CRBSI), CVC removal, adverse events related to the lock solution, and the 30-day case fatality rate. CVC lock solution with taurolidine-citrate-heparin was associated with less colonization of the CVC hubs than that with placebo, with no statistically significant differences: 4.1%, versus 10.1% (relative risk [RR] = 0.41, 95% confidence interval [CI] = 0.11 to 1.52), with a cumulative incidence of 4.17 (95% CI = 0.87 to 11.70) and 10.14 (95% CI = 4.18 to 19.79), respectively. There were no significant differences regarding the secondary endpoints. Only three episodes of CRBSI occurred during the study period. No adverse events related to the administration of the lock solution occurred. In this trial involving high-risk patients carrying nontunneled CVCs, the use of taurolidine-citrate-heparin did not show a benefit over the use of placebo. Nevertheless, the safety of this prevention strategy and the trend toward less hub colonization in the taurolidine-citrate-heparin group raise the interest in assessing its efficacy in centers with higher rates of CRBSI. (This study has been registered in ISRCTN under identifier ISRCTN47102251.) | Versión del editor: | http://doi.org/10.1128/AAC.01521-19 | URI: | http://hdl.handle.net/10261/229155 | DOI: | 10.1128/AAC.01521-19 | Identificadores: | doi: 10.1128/AAC.01521-19 issn: 0066-4804 e-issn: 1098-6596 |
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