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| Título: | A method for tailoring a DNA sequence to obtain species-specific nucleosome positioning |
Autor: | Antequera, Francisco CSIC ORCID; Miguel Quintales, Luis Antonio | Fecha de publicación: | 8-feb-2018 | Citación: | WO2018024749 A1 | Resumen: | The present invention relates to a method for obtaining the DNA sequence pattern determining the nucleosome positioning characteristic of a particular eukaryotic species. It further relates to a method for tailoring coding and/or non-coding DNA sequences to obtain the nucleosome positioning characteristic of a given eukaryotic species. In addition, it also relates to a method of codon optimization based on the modification of nucleosome positioning of a coding and/or non-coding DNA sequence for improving its expression in a host eukaryotic species. | URI: | http://hdl.handle.net/10261/228967 |
| Aparece en las colecciones: | (IBFG) Patentes |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| WO2018024749A1.pdf | 7,12 MB | Adobe PDF |  Visualizar/Abrir |
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