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Título: | Development and plasticity of the corpus callosum |
Autor: | León-Reyes, Noelia S. de; Bragg-Gonzalo, Lorena; Nieto, Marta | Palabras clave: | Agenesis Axonal guidance and plasticity Callosal projecting neurons Corpus callosum Cortex Development Interhemispheric |
Fecha de publicación: | sep-2020 | Editor: | Company of Biologists | Citación: | Development 147: dev189738 (2020) | Resumen: | The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian commissural tract. It facilitates bilateral sensory integration and higher cognitive functions, and is often affected in neurodevelopmental diseases. Here, we review the mechanisms that contribute to the development of CC circuits in animal models and humans. These species comparisons reveal several commonalities. First, there is an early period of massive axonal projection. Second, there is a postnatal temporal window, varying between species, in which early callosal projections are selectively refined. Third, sensory-derived activity influences axonal refinement. We also discuss how defects in CC formation can lead to mild or severe CC congenital malformations. | Descripción: | © 2020. Published by The Company of Biologists Ltd | Versión del editor: | http://dx.doi.org/10.1242/dev.189738 | URI: | http://hdl.handle.net/10261/228916 | DOI: | 10.1242/dev.189738 | ISSN: | 0950-1991 | E-ISSN: | 1477-9129 |
Aparece en las colecciones: | (CNB) Artículos |
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Development_Leon_PV_Art2020.pdf | 1,47 MB | Adobe PDF | Visualizar/Abrir |
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