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dc.contributor.authorCasado, Concepción-
dc.contributor.authorGálvez, Cristina-
dc.contributor.authorPernas, María-
dc.contributor.authorTarancón-Díez, Laura-
dc.contributor.authorRodríguez, Carmen-
dc.contributor.authorSánchez-Merino, Víctor-
dc.contributor.authorVera, Mar-
dc.contributor.authorOlivares, Isabel-
dc.contributor.authorPablo-Bernal, Rebeca de-
dc.contributor.authorMerino-Mansilla, Alberto-
dc.contributor.authorRomero, Jorge del-
dc.contributor.authorLorenzo-Redondo, Ramón-
dc.contributor.authorRuiz-Mateos, Ezequiel-
dc.contributor.authorSalgado, María-
dc.contributor.authorMartínez-Picado, Javier-
dc.contributor.authorLópez-Galíndez, Cecilio-
dc.date.accessioned2021-02-04T12:20:19Z-
dc.date.available2021-02-04T12:20:19Z-
dc.date.issued2020-02-05-
dc.identifierdoi: 10.1038/s41598-020-58696-y-
dc.identifiere-issn: 2045-2322-
dc.identifier.citationScientific Reports 10: 1902 (2020)-
dc.identifier.urihttp://hdl.handle.net/10261/228602-
dc.description.abstractElite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. We define exceptional EC (EEC) as HIV-1 subjects who maintain the EC characteristics without disease progression for more than 25 years. We analyzed three EEC, diagnosed between 1988 and 1992, who never showed signs of clinical disease progression in absence of any antiretroviral treatment. A comprehensive clinical, virological, and immunological study was performed. The individuals simultaneously exhibited ≥3 described host protective alleles, low levels of total HIV-1 DNA (<20 copies/106 CD4+ T-cells) without evidence of replication-competent viruses (<0.025 IUPM), consistent with high levels of defective genomes, strong cellular HIV-1-specific immune response, and a high poly-functionality index (>0.50). Inflammation levels of EEC were similar to HIV-1 negative donors. Remarkably, they showed an exceptional lack of viral evolution and 8-fold lower genetic diversity (<0.01 s/n) in env gene than other EC. We postulate that these EEC represent cases of spontaneous functional HIV-1 cure. A non-functional and non-genetically evolving viral reservoir along with an HIV-1-specific immune response seems to be key for the spontaneous functional cure.-
dc.description.sponsorshipWork in Centro Nacional de Microbiologia (ISCIII) was supported by grants SAF (2016–77894-R) from Ministerio de Economia y Competitividad (MINECO) (Spain) and Fondo de Investigación Sanitaria (FIS)-Instituto de Salud CarlosIII, grant FIS (PI 13/02269, ISCIII) and in part by the RIS-RETIC grants RD12/0017/0028 and RD16CIII/0002/0005 funded by the ISCIII-FEDER. MP has a contract of RIS-RETIC RD16CIII/0002/0005. This work was supported by grants from the MINECO, FIS-Instituto de Salud CarlosIII, Fondos Europeos para el Desarrollo Regional, FEDER, grant numbers PI16/00684, PI19/01127, CPII014/00025 to ER-M. and FI14/00431 to LT-D.; the Gilead Fellowship Program (grant numbers GLD17/00299); the Red de Investigación en Sida (grant number RD16/0025/0020). ER-M. is supported by Consejería de Salud y Bienestar Social of Junta de Andalucía through the Nicolás Monardes Program (C-0032/17). Research in VS-M group was supported by Fondo de Investigación Sanitaria (FIS)-Instituto de Salud Carlos III, grant FIS (PI 17CIII/00049). Grifols partially supported work in the AIDS Research Institute IrsiCaixa.-
dc.languageeng-
dc.publisherSpringer Nature-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-77894-R-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titlePermanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure-
dc.typeartículo-
dc.identifier.doi10.1038/s41598-020-58696-y-
dc.relation.publisherversionhttp://doi.org/10.1038/s41598-020-58696-y-
dc.date.updated2021-02-04T12:20:19Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderRed Española de Investigación en SIDA-
dc.contributor.funderEuropean Commission-
dc.contributor.funderJunta de Andalucía-
dc.contributor.funderJunta de Andalucía-
dc.contributor.funderGrifols-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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