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Título: | Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange |
Autor: | Canal-Martín, Andrea CSIC ORCID; Pérez-Fernández, Ruth CSIC ORCID | Fecha de publicación: | 8-ene-2021 | Editor: | Springer Nature | Citación: | Nature Communications 12 (1) 163 (2021) | Resumen: | Dynamic combinatorial chemistry applied to biological environments requires the exchange chemistry of choice to take place under physiological conditions. Thiol-disulfide exchange, one of the most popular dynamic combinatorial chemistries, usually needs long equilibration times to reach the required equilibrium composition. Here we report selenocystine as a catalyst mimicking Nature's strategy to accelerate thiol-disulfide exchange at physiological pH and low temperatures. Selenocystine is able to accelerate slow thiol-disulfide systems and to promote the correct folding of an scrambled RNase A enzyme, thus broadening the practical range of pH conditions for oxidative folding. Additionally, dynamic combinatorial chemistry target-driven self-assembly processes are tested using spermine, spermidine and NADPH (casting) and glucose oxidase (molding). A non-competitive inhibitor is identified in the glucose oxidase directed dynamic combinatorial library. | Descripción: | 12 p.-9 fig. | Versión del editor: | https://doi.org/10.1038/s41467-020-20415-6 | URI: | http://hdl.handle.net/10261/228321 | DOI: | 10.1038/s41467-020-20415-6 | E-ISSN: | 2041-1723 |
Aparece en las colecciones: | (CIB) Artículos |
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Nature Communications_Canal-Martín_2021.pdf | Artículo principal | 2,21 MB | Adobe PDF | Visualizar/Abrir |
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