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Cranial and extracranial giant cell arteritis share similar HLA-DRB1 association

AuthorsPrieto-Peña, D.; Remuzgo-Martínez, S.; Ocejo-Vinyals, J. Gonzalo; Atienza-Mateo, B.; Muñoz-Jiménez, Alejandro; Ortiz-Sanjuán, Francisco; Romero-Yuste, Susana; Moriano, Clara; Galíndez-Agirregoikoa, E.; Miranda-Filloy, J. A.; Blanco, R.; Gualillo, O.; Martín, J.; Castañeda, S.; López-Mejías, Raquel; González-Gay, M. A.
KeywordsGiant cell arteritis
Large vessel vasculitis
HLA, Genetics
Issue Date2020
CitationSeminars in Arthritis and Rheumatism 50: 897- 901 (2020)
AbstractObjective:To determine whether giant cell arteritis (GCA) patients with the typical pattern of cranial ischemicmanifestations and those with the extracranial large-vessel-vasculitis (LVV)-GCA phenotype exhibit differentHLA-DRB1association.Methods:178 biopsy-proven GCA patients who had cranial ischemic features but no LVV manifestations, 100patients with LVV-GCA without cranial ischemic manifestations and 486 ethnically matched healthy controlswere recruited. All patients and controls were Spanish of European ancestry. We comparedHLA-DRB1pheno-type frequencies between the three groups.Results:Both GCA subgroups had well-differentiated clinical features. Patients with LVV-GCA were younger(68.0§10.0 yearsversus74.0§10.4 years;p<0.01) and presented more commonly with polymyalgia rheu-matica symptoms (81%versus39.3%;p<0.01) than those with the classic cranial GCA phenotype.HLA-DRB1*04phenotype frequency was significantly increased in patients with classic cranial GCA compared tocontrols (42.1%versus23.5%, respectively;p<0.01; odds ratio-OR [95% confidence interval-CI] = 2.38[1.623.47]). This association was mainly due to theHLA-DRB1*04:01allele (20.8%versus5.3%, respectively;p<0.01; OR [95% CI] = 4.64 [2.638.26]).HLA-DRB1*04association was also observed in LVV-GCA patientswhen compared to controls (46.0%versus23.5%, respectively;p<0.01; OR [95% CI] = 2.78 [1.734.44]).
Publisher version (URL)http://dx.doi.org/10.1016/j.semarthrit.2020.07.004
Identifiersdoi: 10.1016/j.semarthrit.2020.07.004
issn: 0049-0172
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