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Title

In vitro and in vivo antibacterial activity of gliotoxin alone and in combination with antibiotics against staphylococcus aureus

AuthorsEsteban, Patricia; Redrado, Sergio; Comas, Laura; Domingo, María Pilar; Millán-Lou, María Isabel; Seral, Cristina; Algarate, Sonia; López Gómez, Concepción; Rezusta, Antonio; Pardo, Julián; Arias, Maykel; Gálvez Buerba, Eva Mª CSIC ORCID
KeywordsGliotoxin
Staphylococcus aureus
MRSA
VISA
Vancomycin
Synergism
Resistance
Antibiotics
Issue Date23-Jan-2021
PublisherMultidisciplinary Digital Publishing Institute
CitationToxins 13(2): 85 (2021)
AbstractMultidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes of hospital-acquired and community infections and pose a challenge to the human health care system. Therefore, it is important to find new drugs that show activity against these bacteria, both in monotherapy and in combination with other antimicrobial drugs. Gliotoxin (GT) is a mycotoxin produced by Aspergillus fumigatus and other fungi of the Aspergillus genus. Some evidence suggests that GT shows antimicrobial activity against S. aureus in vitro, albeit its efficacy against multidrug-resistant strains such as MRSA or vancomycin-intermediate S. aureus (VISA) strainsis not known. This work aimed to evaluate the antibiotic efficacy of GT as monotherapy or in combination with other therapeutics against MRSA in vitro and in vivo using a Caenorhabditis elegans infection model.
Description7 figures, 2 tables.
Publisher version (URL)http://dx.doi.org/10.3390/toxins13020085
URIhttp://hdl.handle.net/10261/227950
E-ISSN2072-6651
Identifiersdoi: 10.3390/toxins13020085
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