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Title

Altering model cell membranes by means of localized magnetic heating

AuthorsRuiz Rincón, Silvia; González-Orive, Alejandro; Grazú, Valeria; Fratila, Raluca M.; Fuente, Jesús M. de la; Cea, Pilar
Issue Date2020
PublisherElsevier
CitationColloids and Surfaces B: Biointerfaces 196: 111315 (2020)
AbstractIsolated iron oxide magnetic nanoparticles (MNPs), 12 nm in diameter, coated with oleic acid molecules as capping agents have been deposited by the Langmuir-Blodgett (LB) method onto a model cell membrane incorporating 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and Cholesterol (Chol) in the 1:1 ratio, which was also fabricated by the LB technique. Atomic Force Microscopy (AFM) experiments showed that the application of an alternating magnetic field results in the embedding of the MNPs through the phospholipidic layer. These experimental results reveal that the heating of individual MNPs may induce a local increase in the fluidity of the film with a large control of the spatial and temporal specificity.
Publisher version (URL)https://doi.org/10.1016/j.colsurfb.2020.111315
URIhttp://hdl.handle.net/10261/227000
DOIhttp://dx.doi.org/10.1016/j.colsurfb.2020.111315
ISSN0927-7765
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