English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/226682
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorNicolás-Ávila, José A.-
dc.contributor.authorLechuga, Ana-
dc.contributor.authorSanchez-Díaz, María-
dc.contributor.authorDíaz-García, Elena-
dc.contributor.authorSantiago, Demetrio J.-
dc.contributor.authorRubio-Ponce, Andrea-
dc.contributor.authorLiangYao Li, Jackson-
dc.contributor.authorBalachander, Akhila-
dc.contributor.authorQuintana, Juan A.-
dc.contributor.authorMartínez de Mena, Raquel-
dc.contributor.authorCastejón-Vega, Beatriz-
dc.contributor.authorPun-García, Andrés-
dc.contributor.authorTravés, Paqui G.-
dc.contributor.authorBonzón-Kulichenko, Elena-
dc.contributor.authorGarcía-Marqués, Fernando-
dc.contributor.authorCussó, Lorena-
dc.contributor.authorGonzález, Noelia A.-
dc.contributor.authorGonzález-Guerra, Andrés-
dc.contributor.authorRoche-Molina, Marta-
dc.contributor.authorMartin-Salamanca, Sandra-
dc.contributor.authorCrainiciuc, Georgiana-
dc.contributor.authorGuzmán, Gabriela-
dc.contributor.authorLarrazabal, Jagoba-
dc.contributor.authorHerrero-Galán, Elías-
dc.contributor.authorAlegre-Cebollada, Jorge-
dc.contributor.authorLemke, Greg-
dc.contributor.authorRothlin, Carla V.-
dc.contributor.authorJiménez-Borreguero, Luis J.-
dc.contributor.authorReyes, Guillermo-
dc.contributor.authorCastrillo, Antonio-
dc.contributor.authorDesco, Manuel-
dc.contributor.authorMuñoz-Cánoves, Pura-
dc.contributor.authorIbáñez, Borja-
dc.contributor.authorTorres, Miguel-
dc.contributor.authorGuan Ng, Lai-
dc.contributor.authorPriori, Silvia G.-
dc.contributor.authorBueno, Héctor-
dc.contributor.authorVázquez, Jesús-
dc.contributor.authorCordero, Mario D.-
dc.contributor.authorBernal, Juan-
dc.contributor.authorEnríquez, José Antonio-
dc.contributor.authorHidalgo, Andrés-
dc.date.accessioned2021-01-14T10:50:19Z-
dc.date.available2021-01-14T10:50:19Z-
dc.date.issued2020-10-01-
dc.identifier.citationCell 183(1): 94-109.e23 (2020)-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10261/226682-
dc.description.abstractCardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, through a process driven by the cardiomyocyte's autophagy machinery that was enhanced during cardiac stress. Depletion of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective elimination of mitochondria from the myocardial tissue, activation of the inflammasome, impaired autophagy, accumulation of anomalous mitochondria in cardiomyocytes, metabolic alterations, and ventricular dysfunction. Thus, we identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function. Video Abstract: [Figure presented] A system of macrophages in the heart supports cardiomyocyte health by phagocytosing exopher particles ejected from cardiomyocytes that contain defective mitochondria, among other cellular contents.-
dc.description.sponsorshipThis study was supported by Intramural grants from the Severo Ochoa program (IGP-SO); grants SAF2015-71878-REDT and SAF2014-56819-R from the Ministerio de Ciencia e Innovacion (MICINN) to A.C.; European Research Council grant EU-rhythmy (ERC-ADG-2014-ID:669387) to S.G.P., and MATRIX (ERC-COG-2018-ID: 819775) to B.I.; L.G.N. is supported by SIgN core funding from A∗STAR; grant BFU2016-75144-R from the Ministry of Science and Innovation to J.A.B,; grants PGC2018-096486-B-I00 and RD16/0011/0019 (ISCIII) from MICINN, TNE-17CVD04 from the Leducq Foundation, and S2017/BMD-3875 from the Comunidad de Madrid to M.T; intramural grant TPC/O-SO and grants SAF2015-65633-R, RTI2018-099357-B-I00, and HFSP (RGP0016/2018) to J.A.E.; intramural grant IGP-SO to J.A.-C. and A.H.; BIO2017-83640-P and RYC-2014-16604 to J.A-C; grants PRB3 (IPT17/0019-ISCIII-SGEFI/ERDF, ProteoRed) from the Carlos III Institute of Health and Fondo de Investigaciones Sanitarias, BIO2015-67580-P and PGC2018-097019-B-I00 from MICINN to J.V.; RTI2018-096068 from MICINN, AFM, MDA, LaCaixa-HR17-00040, UPGRADE-H2020-825825, and European Research Council (ERC-741538) to P.M.C.; S2017/BMD-3867 RENIM-CM from the Comunidad de Madrid and cofunded with European structural and investment funds to M.D.; 120/C/2015-20153032 from Fundació la Marató de TV3, SAF2015-65607-R and RTI2018-095497-B-I00 from MICINN, HR17_00527 from La Caixa Foundation, and TNE-18CVD04 from the Leducq Foundation to A.H.; C.V.R. is a Howard Hughes Medical Institute Faculty Scholar; J.A.N-A is supported by fellowship SVP-2014-068595, A.V.L.-V. by SVP-2013-068089, L.E.-M. by FJCI-2016-29384, and A.R.-P. by BES-2016-076635, all from MICINN; and the CNIC International Postdoctoral Program (EU grant agreement 600396 to D.J.S.). The CNIC is supported by the MICINN and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MICINN award SEV-2015-0505).-
dc.languageeng-
dc.publisherElsevier-
dc.relationMINECO/ICTI2013-2016/SAF2015-71878-REDT-
dc.relationMINECO/ICTI2013-2016/SAF2014-56819-R-
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/669387-
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/819775-
dc.relationMINECO/ICTI2013-2016/BFU2016-75144-R-
dc.relationMICIU/ICTI2017-2020/PGC2018-096486-B-I00-
dc.relationPGC2018-096486-B-I00/AEI/10.13039/501100011033-
dc.relationS2017/BMD-3875/REANIMA-CM-
dc.relationMINECO/ICTI2013-2016/SAF2015-65633-R-
dc.relationMICIU/ICTI2017-2020/RTI2018-099357-B-I00-
dc.relationRTI2018-099357-B-I00/AEI/10.13039/501100011033-
dc.relationMICIU/ICTI2017-2020/BIO2017-83640-P-
dc.relationBIO2017-83640-P/AEI/10.13039/501100011033-
dc.relationMINECO/ICTI2013-2016/RYC-2014-16604-
dc.relationMINECO/ICTI2013-2016/BIO2015-67580-P-
dc.relationMICIU/ICTI2017-2020/PGC2018-097019-B-I00-
dc.relationPGC2018-097019-B-I00/AEI/10.13039/501100011033-
dc.relationMICIU/ICTI2017-2020/RTI2018-096068-
dc.relationRTI2018-096068/AEI/10.13039/501100011033-
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/825825-
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/741538-
dc.relationS2017/BMD-3867RENIM-CM-
dc.relationMINECO/ICTI2013-2016/SAF2015-65607-R-
dc.relationMICIU/ICTI2017-2020/RTI2018-095497-B-I00-
dc.relationRTI2018-095497-B-I00/AEI/10.13039/501100011033-
dc.relationMINECO/ICTI2013-2016/SVP-2014-068595-
dc.relationMINECO/ICTI2013-2016/SVP-2013-068089-
dc.relationMINECO/ICTI2013-2016/FJCI-2016-29384-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/600396-
dc.relationMINECO/ICTI2013-2016/SEV-2015-0505-
dc.relation.isversionofPostprint-
dc.rightsopenAccessen_EN
dc.subjectMacrophage-
dc.subjectMitochondria-
dc.subjectAutophagy-
dc.subjectProteostasis-
dc.subjectPhagocytosis-
dc.subjectHeart-
dc.titleA Network of Macrophages Supports Mitochondrial Homeostasis in the Heart-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.cell.2020.08.031-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.cell.2020.08.031-
dc.identifier.e-issn1097-4172-
dc.date.updated2021-01-14T10:50:20Z-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderEuropean Research Council-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)-
dc.contributor.funderAgencia Estatal de Investigación (España)-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderFondation Leducq-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderLa Caixa-
dc.contributor.funderFundació La Marató de TV3-
dc.contributor.funderObra Social la Caixa-
dc.contributor.funderHoward Hughes Medical Institute-
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100005884es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001674es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008666es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000011es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
NetworkNicolas_Postprint2020.pdf1,65 MBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.