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dc.contributor.authorLi, Yufenes_ES
dc.contributor.authorLi, Songweies_ES
dc.contributor.authorCuadrado, Cristinaes_ES
dc.contributor.authorGao, Chenglonges_ES
dc.contributor.authorWu, Qihaoes_ES
dc.contributor.authorLi, Xiaolues_ES
dc.contributor.authorPang, Taoes_ES
dc.contributor.authorHernández Daranas, Antonioes_ES
dc.contributor.authorGuo, Yueweies_ES
dc.contributor.authorLi, Xuwenes_ES
dc.date.accessioned2021-01-11T10:27:38Z-
dc.date.available2021-01-11T10:27:38Z-
dc.date.issued2020-11-23-
dc.identifier.citationChinese Chemical Letters 32(1): 271-276 (2021)es_ES
dc.identifier.issn1001-8417-
dc.identifier.urihttp://hdl.handle.net/10261/226344-
dc.description.abstractFive novel biscembranoids, ximaolides H–L (1–5), along with four known related compounds (6–9) were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of the new compounds were determined by extensive spectroscopic analysis, quantum chemical calculations, and/or by comparing their CD spectra with those of the known compounds. Compounds 1 and 2 are the first examples of biscembranoids bearing a 1, 35-bridged lactone moiety, 4 is the first biscembranoid comprising an uncommon oxetane ring, and 5 represents the first 36-peroxyl biscembranoid. Ximaolides I (2), K (4) and F (9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-α protein release in RAW264.7 macrophages.es_ES
dc.description.sponsorshipThis research work was financially supported by the National Natural Science Foundation of China (NSFC, Nos. 81991521, 8202290170, 42076099), the NSFC/CNRS (Centre national de la recherche scientifique) Joint Project (No. 81811530284), the National Key Research and Development Program of China (No. 2018YFC0310903), and the SKLDR/ SIMM Project (No. SIMM1903ZZ-04). X.-W. Li is also thankful for the Shanghai Rising-Star Program (No. 20QA1411100) and SA-SIBS Scholarship Program. We thank Prof. X.-B. Li from Hainan University for the taxonomic identification of the soft coral material.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rightsclosedAccesses_ES
dc.subjectSoft corales_ES
dc.subjectSarcophyton tortuosumes_ES
dc.subjectBiscembranoides_ES
dc.subjectStereochemistryes_ES
dc.subjectAnti-inflammatoryes_ES
dc.titlePolyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistryes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.cclet.2020.11.037-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.cclet.2020.11.037es_ES
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/es/es_ES
dc.contributor.funderNational Natural Science Foundation of Chinaes_ES
dc.contributor.funderCentre National de la Recherche Scientifique (France)es_ES
dc.contributor.funderNational Key Research and Development Program (China)es_ES
dc.contributor.funderChinese Academy of Scienceses_ES
dc.contributor.funderHainan Universityes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004794es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002367es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100005693es_ES
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