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Título

Increase of the in vitro bioaccessibility of carotenoids through delivering of inclusion complexes

AutorFernández García, Elisabet ; Carvajal-Lérida, Irene ; Pérez Gálvez, Antonio
Palabras clavecarotenoid
bioaccessibility
in vitro assimilation
cyclodextrin
Fecha de publicación26-mar-2010
ResumenSeveral factors are implicated in the bioaccessibility of carotenoids (1) and the efficiency of the process is generally low. Some approaches have been developed to increase bioaccessibility, including the application of either encapsulation or emulsion formulae (2). Inclusion complexes are a plausible alternative to achieve the same goal. When inclusion complexes of different carotenoids (beta-carotene, lutein and lycopene) were delivered to brush border membrane vesicles (BBMV) an increased efficiency of bioaccessibility was achieved in comparison with the one achieved when carotenoids were delivered as micelles preparations. As both the inclusion complex and micelles preparations are directly shuttled through the hydrophilic environment, enhancement of the bioaccessibility could be consequence of a fast restock of free carotenoids in the surrounding of the cellular membrane when they are initially delivered as inclusion complexes. However, depending on the carotenoid a different increased efficiency was observed. Thus, micellar lutein showed the lowest efficiency but the highest rise when delivered as inclusion complex (increase of 185%). This fact may be due to a distinct dissociation constant of the carotenoids from the host compound (lower for beta-carotene and lycopene and higher for lutein). It may conclude that formulation of carotenoids as inclusion complexes is an efficient formula to increase bioaccessibility of these lipophilic compounds. References 1 Castenmiller, West, Annual Reviews of Nutrition, 18, 19-38 (1998). 2 Fernández-García, Rincón, Pérez-Gálvez, Journal of Agricultural and Food Chemistry, 56, 10384-10390 (2008).
URIhttp://hdl.handle.net/10261/22628
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