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Title

Marked changes in innate immunity associated with a mild course of COVID-19 in identical twins with athymia and absent circulating T cells

AuthorsColmenero-Velázquez, Argentina; Esteso, Gloria; Rosal, Teresa del; Calvo Apalategui, Ane; Reyburn, H. T. ; López-Granados, Eduardo
Issue Date3-Dec-2020
PublisherElsevier
CitationJournal of Allergy and Clinical Immunology (2020)
AbstractWe read with interest the recent articles from Zhang et al and Bastard et al revealing impaired type I IFN immunity as a major risk for severe coronavirus disease 2019 (COVID-19)1,2; however, the relative importance of innate and adaptive immunity for viral control is difficult to evaluate.3 A diagnosis of mild COVID-19 in 2 identical twin neonates with an uncommon primary immunodeficiency (PID) that causes athymia and almost complete T-cell lymphopenia allowed study of innate immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the absence of adaptive immunity.
Publisher version (URL)https://doi.org/10.1016/j.jaci.2020.11.007
URIhttp://hdl.handle.net/10261/225833
DOIhttp://dx.doi.org/10.1016/j.jaci.2020.11.007
ISSN0091-6749
Appears in Collections:(CNB) Artículos
(VICYT) Colección Especial COVID-19
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