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Nano-delivery systems based on carvacrol prodrugs and fibrous clays

AuthorsEusepi, Piera; Marinelli, Lisa; Borrego Sánchez, Ana CSIC ORCID; García-Villén, Fátima; Rayhane, Ben Khalifa; Cacciatore, Ivana; Viseras, César; Di Stefano, Antonio
Issue Date23-May-2020
PublisherElsevier BV
CitationJournal of Drug Delivery Science and Technology 58: 101815 (2020)
AbstractThe fibrous silicates, Palygorskite and Sepiolite, were investigated as low-cost nanocarriers for three carvacrol prodrugs to ameliorate their pharmacokinetic and biopharmaceutic profiles. Adsorption equilibrium studies were performed in order to obtain a drug-clay hybrid system. These hybrid systems were characterized by thermal analysis, X-ray diffraction, and Fourier transform infrared spectroscopy, to study the degree and kind of interactions between the organic and inorganic components. In vitro release and chemical stability of prodrug-clay hybrids were studied in physiological gastrointestinal simulated fluids. The results showed an improvement of the chemical stability of prodrugs in hybrids systems, as well as a sustained release and a retained bioconversion of the prodrugs into the pharmacologically active carvacrol, to improve the antimicrobial activity.
Publisher version (URL)http://dx.doi.org/10.1016/j.jddst.2020.101815
Identifiersdoi: 10.1016/j.jddst.2020.101815
issn: 1773-2247
Appears in Collections:(IACT) Artículos
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