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Título: | Nano-delivery systems based on carvacrol prodrugs and fibrous clays |
Autor: | Eusepi, Piera; Marinelli, Lisa; Borrego Sánchez, Ana CSIC ORCID; García-Villén, Fátima; Rayhane, Ben Khalifa; Cacciatore, Ivana; Viseras, César; Di Stefano, Antonio | Palabras clave: | Carvacrol Prodrugs Clays Palygorskite Sepiolite |
Fecha de publicación: | 23-may-2020 | Editor: | Elsevier BV | Citación: | Journal of Drug Delivery Science and Technology 58: 101815 (2020) | Resumen: | The fibrous silicates, Palygorskite and Sepiolite, were investigated as low-cost nanocarriers for three carvacrol prodrugs to ameliorate their pharmacokinetic and biopharmaceutic profiles. Adsorption equilibrium studies were performed in order to obtain a drug-clay hybrid system. These hybrid systems were characterized by thermal analysis, X-ray diffraction, and Fourier transform infrared spectroscopy, to study the degree and kind of interactions between the organic and inorganic components. In vitro release and chemical stability of prodrug-clay hybrids were studied in physiological gastrointestinal simulated fluids. The results showed an improvement of the chemical stability of prodrugs in hybrids systems, as well as a sustained release and a retained bioconversion of the prodrugs into the pharmacologically active carvacrol, to improve the antimicrobial activity. | Versión del editor: | http://dx.doi.org/10.1016/j.jddst.2020.101815 | URI: | http://hdl.handle.net/10261/225044 | DOI: | 10.1016/j.jddst.2020.101815 | Identificadores: | doi: 10.1016/j.jddst.2020.101815 issn: 1773-2247 |
Aparece en las colecciones: | (IACT) Artículos |
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