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Cardiotrophin‐1 contributes to metabolic adaptations through the regulation of lipid metabolism and to the fasting‐induced fatty acid mobilization

AuthorsCarneros, David; Medina-Gómez, Gema; Giralt, Marta; León Camacho, Manuel ; Campbell, Mark; Moreno-Aliaga, María J.; Villarroya, Francesc; Bustos, Matilde
KeywordsAdipose tissue
Fatty acid mobilization
Food restriction
Peroxisome proliferator‐activated receptors
Issue DateDec-2020
PublisherJohn Wiley & Sons
CitationFASEB Journal - Federation of American Societies for Experimental Biology 34 (12): 15875-15887 (2020)
AbstractIt is becoming clear that several human pathologies are caused by altered metabolic adaptations. During liver development, there are physiological changes, from the predominant utilization of glucose (fetal life) to the use of lipids (postnatal life). Fasting is another physiological stress that elicits well‐known metabolic adjustments. We have reported the metabolic properties of cardiotrophin‐1 (CT‐1), a member of the interleukin‐6 family of cytokines. Here, we aimed at analyzing the role of CT‐1 in response to these metabolic changes. We used different in vivo models. Furthermore, a differential study was carried out with wild‐type and CT‐1 null mice in fed (ad libitum) and food‐restricted conditions. We demonstrated that Ct‐1 is a metabolic gene induced in the liver via PPARα in response to lipids in mice (neonates‐ and food‐restricted adults). We found that Ct‐1 mRNA expression in white adipose tissue directly involved PPARα and PPARγ. Finally, the physiological role of CT‐1 in fasting is confirmed by the impaired food restriction‐induced adipose tissue lipid mobilization in CT‐1 null mice. Our findings support a previously unrecognized physiological role of CT‐1 in metabolic adaptations, through the regulation of lipid metabolism and contributes to fasting‐induced free fatty acid mobilization.
Description5 Figuras.-- 1 Tabla
Publisher version (URL)http://dx.doi.org/10.1096/fj.202000109R
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